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Distance-dependent cellular uptake of oligoproline-based homobivalent ligands targeting GPCRs - an experimental and computational analysis
Dobitz, S., Wilhelm, P., Romantini, N., De Foresta, M., Walther, C., Ritler, A., … Wennemers, H. (2020). Distance-dependent cellular uptake of oligoproline-based homobivalent ligands targeting GPCRs - an experimental and computational analysis. Bioconjugate Chemistry, 31(10), 2431-2438. https://doi.org/10.1021/acs.bioconjchem.0c00484
Triazolo-peptidomimetics: novel radiolabeled minigastrin analogs for improved tumor targeting
Grob, N. M., Häussinger, D., Deupi, X., Schibli, R., Behe, M., & Mindt, T. L. (2020). Triazolo-peptidomimetics: novel radiolabeled minigastrin analogs for improved tumor targeting. Journal of Medicinal Chemistry, 63(9), 4484-4495. https://doi.org/10.1021/acs.jmedchem.9b01936
GPCRmd uncovers the dynamics of the 3D-GPCRome
Rodríguez-Espigares, I., Torrens-Fontanals, M., Tiemann, J. K. S., Aranda-García, D., Ramírez-Anguita, J. M., Stepniewski, T. M., … Selent, J. (2020). GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature Methods, 17, 777-787. https://doi.org/10.1038/s41592-020-0884-y
Elucidating the structure−activity relationship of the pentaglutamic acid sequence of minigastrin with cholecystokinin receptor subtype 2
Ritler, A., Shoshan, M. S., Deupi, X., Wilhelm, P., Schibli, R., Wennemers, H., & Béhé, M. (2019). Elucidating the structure−activity relationship of the pentaglutamic acid sequence of minigastrin with cholecystokinin receptor subtype 2. Bioconjugate Chemistry, 30(3), 657-666. https://doi.org/10.1021/acs.bioconjchem.8b00849
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture
Hilbert, M., Noga, A., Frey, D., Hamel, V., Guichard, P., Kraatz, S. H. W., … Steinmetz, M. O. (2016). SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture. Nature Cell Biology, 18(4), 393-403. https://doi.org/10.1038/ncb3329
Backbone NMR reveals allosteric signal transduction networks in the β<sub>1</sub>-adrenergic receptor
Isogai, S., Deupi, X., Opitz, C., Heydenreich, F. M., Tsai, C. J., Brueckner, F., … Grzesiek, S. (2016). Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor. Nature, 530(7589), 237-241. https://doi.org/10.1038/nature16577
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
Venkatakrishnan, A. J., Deupi, X., Lebon, G., Heydenreich, F. M., Flock, T., Miljus, T., … Babu, M. M. (2016). Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region. Nature, 536(7617), 484-487. https://doi.org/10.1038/nature19107
Conformational activation of visual rhodopsin in native disc membranes
Malmerberg, E., Bovee-Geurts, P. H. M., Katona, G., Deupi, X., Arnlund, D., Wickstrand, C., … Neutze, R. (2015). Conformational activation of visual rhodopsin in native disc membranes. Science Signaling, 8(367), ra26 (9 pp.). https://doi.org/10.1126/scisignal.2005646
A molecular pharmacologist's guide to G protein–coupled receptor crystallography
Piscitelli, C. L., Kean, J., de Graaf, C., & Deupi, X. (2015). A molecular pharmacologist's guide to G protein–coupled receptor crystallography. Molecular Pharmacology, 88(3), 536-551. https://doi.org/10.1124/mol.115.099663
Probing Gα<sub>i1</sub> protein activation at single-amino acid resolution
Sun, D., Flock, T., Deupi, X., Maeda, S., Matkovic, M., Mendieta, S., … Veprintsev, D. B. (2015). Probing Gαi1 protein activation at single-amino acid resolution. Nature Structural and Molecular Biology, 22(9), 686-694. https://doi.org/10.1038/nsmb.3070
A stitch in time
Deupi, X. (2014). A stitch in time. Nature Chemistry, 6(1), 7-8. https://doi.org/10.1038/nchem.1832
Relevance of rhodopsin studies for GPCR activation
Deupi, X. (2014). Relevance of rhodopsin studies for GPCR activation. Biochimica et Biophysica Acta: Bioenergetics, 1837(5), 674-682. https://doi.org/10.1016/j.bbabio.2013.09.002
Retinal proteins - you can teach an old dog new tricks
Heberle, J., Deupi, X., & Schertler, G. (2014). Retinal proteins - you can teach an old dog new tricks. Biochimica et Biophysica Acta: Bioenergetics, 1837(5), 531-532. https://doi.org/10.1016/j.bbabio.2014.02.019
Structural and functional characterization of alternative transmembrane domain conformations in VEGF receptor 2 activation
Manni, S., Mineev, K. S., Usmanova, D., Lyukmanova, E. N., Shulepko, M. A., Kirpichnikov, M. P., … Ballmer-Hofer, K. (2014). Structural and functional characterization of alternative transmembrane domain conformations in VEGF receptor 2 activation. Structure, 22(8), 1077-1089. https://doi.org/10.1016/j.str.2014.05.010
Functional map of arrestin-1 at single amino acid resolution
Ostermaier, M. K., Peterhans, C., Jaussi, R., Deupi, X., & Standfuss, J. (2014). Functional map of arrestin-1 at single amino acid resolution. Proceedings of the National Academy of Sciences of the United States of America PNAS, 111(5), 1825-1830. https://doi.org/10.1073/pnas.1319402111
Structure of β-Adrenergic receptors
Brueckner, F., Piscitelli, C. L., Tsai, C. J., Standfuss, J., Deupi, X., & Schertler, G. F. X. (2013). Structure of β-Adrenergic receptors. In P. M. Conn (Ed.), Methods in enzymology: Vol. 520. G protein coupled receptors. Structure (pp. 117-151). https://doi.org/10.1016/B978-0-12-391861-1.00006-X
Insights into congenital stationary night blindness based on the structure of G90D rhodopsin
Singhal, A., Ostermaier, M. K., Vishnivetskiy, S. A., Panneels, V., Homan, K. T., Tesmer, J. J. G., … Standfuss, J. (2013). Insights into congenital stationary night blindness based on the structure of G90D rhodopsin. EMBO Reports, 14(6), 520-526. https://doi.org/10.1038/embor.2013.44
Molecular signatures of G-protein-coupled receptors
Venkatakrishnan, A. J., Deupi, X., Lebon, G., Tate, C. G., Schertler, G. F., & Babu, M. M. (2013). Molecular signatures of G-protein-coupled receptors. Nature, 494(7436), 185-194. https://doi.org/10.1038/nature11896
Conserved activation pathways in G-protein-coupled receptors
Deupi, X., Standfuss, J., & Schertler, G. (2012). Conserved activation pathways in G-protein-coupled receptors. Biochemical Society Transactions, 40(2), 383-388. https://doi.org/10.1042/BST20120001
Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II
Deupi, X., Edwards, P., Singhal, A., Nickle, B., Oprian, D., Schertler, G., & Standfuss, J. (2012). Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II. Proceedings of the National Academy of Sciences of the United States of America PNAS, 109(1), 119-124. https://doi.org/10.1073/pnas.1114089108