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Matrix metalloproteinase-responsive delivery of PEGylated fibroblast growth factor 2
Gutmann, M., Reinhardt, D., Seidensticker, C., Raschig, M., Hahn, L., Moscaroli, A., … Lühmann, T. (2024). Matrix metalloproteinase-responsive delivery of PEGylated fibroblast growth factor 2. ACS Biomaterials Science & Engineering, 10(1), 156-165. https://doi.org/10.1021/acsbiomaterials.3c01511
A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression
Rigamonti, N., Veitonmäki, N., Domke, C., Barsin, S., Jetzer, S., Abdelmotaleb, O., … Trail, P. A. (2022). A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression. Cancer Immunology Research, 10(5), 626-640. https://doi.org/10.1158/2326-6066.CIR-21-0553
Antibody-guided molecular imaging of <em>Aspergillus </em>lung infections in leukemia patients
Schwenck, J., Maurer, A., Beziere, N., Fiz, F., Boschetti, F., Geistlich, S., … Thornton, C. (2022). Antibody-guided molecular imaging of Aspergillus lung infections in leukemia patients. Journal of Nuclear Medicine, 63(9), 1450-1451. https://doi.org/10.2967/jnumed.121.263251
1,5-Disubstituted 1,2,3-triazoles as amide bond isosteres yield novel tumor-targeting minigastrin analogs
Grob, N. M., Schibli, R., Béhé, M., Valverde, I. E., & Mindt, T. L. (2021). 1,5-Disubstituted 1,2,3-triazoles as amide bond isosteres yield novel tumor-targeting minigastrin analogs. ACS Medicinal Chemistry Letters, 12(4), 585-592. https://doi.org/10.1021/acsmedchemlett.0c00636
Distance-dependent cellular uptake of oligoproline-based homobivalent ligands targeting GPCRs - an experimental and computational analysis
Dobitz, S., Wilhelm, P., Romantini, N., De Foresta, M., Walther, C., Ritler, A., … Wennemers, H. (2020). Distance-dependent cellular uptake of oligoproline-based homobivalent ligands targeting GPCRs - an experimental and computational analysis. Bioconjugate Chemistry, 31(10), 2431-2438. https://doi.org/10.1021/acs.bioconjchem.0c00484
Design of radiolabeled analogs of minigastrin by multiple amide-to-triazole substitutions
Grob, N. M., Schmid, S., Schibli, R., Behe, M., & Mindt, T. L. (2020). Design of radiolabeled analogs of minigastrin by multiple amide-to-triazole substitutions. Journal of Medicinal Chemistry, 63(9), 4496-4505. https://doi.org/10.1021/acs.jmedchem.9b01937
Triazolo-peptidomimetics: novel radiolabeled minigastrin analogs for improved tumor targeting
Grob, N. M., Häussinger, D., Deupi, X., Schibli, R., Behe, M., & Mindt, T. L. (2020). Triazolo-peptidomimetics: novel radiolabeled minigastrin analogs for improved tumor targeting. Journal of Medicinal Chemistry, 63(9), 4484-4495. https://doi.org/10.1021/acs.jmedchem.9b01936
Biodistribution of site-specific PEGylated fibroblast growth factor-2
Lühmann, T., Gutmann, M., Moscaroli, A., Raschig, M., Béhé, M., & Meinel, L. (2020). Biodistribution of site-specific PEGylated fibroblast growth factor-2. ACS Biomaterials Science & Engineering, 6(1), 425-432. https://doi.org/10.1021/acsbiomaterials.9b01248
Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins
Brandl, F., Merten, H., Zimmermann, M., Béhé, M., Zangemeister-Wittke, U., & Plückthun, A. (2019). Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. Journal of Controlled Release, 307, 379-392. https://doi.org/10.1016/j.jconrel.2019.06.030
Succinylated gelatin improves the theranostic potential of radiolabeled exendin-4 in insulinoma patients
Buitinga, M., Jansen, T., van der Kroon, I., Woliner-van der Weg, W., Boss, M., Janssen, M., … Gotthardt, M. (2019). Succinylated gelatin improves the theranostic potential of radiolabeled exendin-4 in insulinoma patients. Journal of Nuclear Medicine, 60(6), 812-816. https://doi.org/10.2967/jnumed.118.219980
An overview of targeted radiotherapy
Grzmil, M., Meisel, A., Behé, M., & Schibli, R. (2019). An overview of targeted radiotherapy. In J. S. Lewis, A. D. Windhorst, & B. M. Zeglis (Eds.), Radiopharmaceutical chemistry (pp. 85-100). https://doi.org/10.1007/978-3-319-98947-1_5
L1CAM. Ein vielversprechendes Zellmembranprotein für therapeutische Interventionen
Grünberg, J., & Terraneo, N. (2019). L1CAM. Ein vielversprechendes Zellmembranprotein für therapeutische Interventionen. Leading Opinions Hämatologie & Onkologie (6), 6-8.
Exendin-4 derivatives with an albumin-binding moiety show decreased renal retention and improved GLP-1 receptor targeting
Kaeppeli, S. A. M., Jodal, A., Gotthardt, M., Schibli, R., & Behe, M. (2019). Exendin-4 derivatives with an albumin-binding moiety show decreased renal retention and improved GLP-1 receptor targeting. Molecular Pharmaceutics, 16(9), 3760-3769. https://doi.org/10.1021/acs.molpharmaceut.9b00271
Elucidating the structure−activity relationship of the pentaglutamic acid sequence of minigastrin with cholecystokinin receptor subtype 2
Ritler, A., Shoshan, M. S., Deupi, X., Wilhelm, P., Schibli, R., Wennemers, H., & Béhé, M. (2019). Elucidating the structure−activity relationship of the pentaglutamic acid sequence of minigastrin with cholecystokinin receptor subtype 2. Bioconjugate Chemistry, 30(3), 657-666. https://doi.org/10.1021/acs.bioconjchem.8b00849
Implementation of a new separation method to produce qualitatively improved &lt;sup&gt;64&lt;/sup&gt;Cu
van der Meulen, N. P., Hasler, R., Blanc, A., Farkas, R., Benešová, M., Talip, Z., … Schibli, R. (2019). Implementation of a new separation method to produce qualitatively improved 64Cu. Journal of Labelled Compounds and Radiopharmaceuticals, 62(8), 460-470. https://doi.org/10.1002/jlcr.3730
Targeting of the cholecystokinin-2 receptor with the minigastrin analog &lt;sup&gt;177&lt;/sup&gt;Lu-DOTA-PP-F11N: does the use of protease inhibitors further improve in vivo distribution?
Sauter, A. W., Mansi, R., Hassiepen, U., Muller, L., Panigada, T., Wiehr, S., … Fani, M. (2018). Targeting of the cholecystokinin-2 receptor with the minigastrin analog 177Lu-DOTA-PP-F11N: does the use of protease inhibitors further improve in vivo distribution? Journal of Nuclear Medicine, 60(3), 393-399. https://doi.org/10.2967/jnumed.118.207845
Radiolabeled &lt;sup&gt;111&lt;/sup&gt;In-FGF-2 is suitable for &lt;em&gt;In Vitro&lt;/em&gt;/&lt;em&gt;Ex Vivo &lt;/em&gt;evaluations and &lt;em&gt;In Vivo &lt;/em&gt;imaging
Moscaroli, A., Jones, G., Lühmann, T., Meinel, L., Wälti, S., Blanc, A., … Béhé, M. (2017). Radiolabeled 111In-FGF-2 is suitable for In Vitro/Ex Vivo evaluations and In Vivo imaging. Molecular Pharmaceutics, 14(3), 639-648. https://doi.org/10.1021/acs.molpharmaceut.6b00913
Dual, site-specific modification of antibodies by using solid-phase immobilized microbial transglutaminase
Spycher, P. R., Amann, C. A., Wehrmüller, J. E., Hurwitz, D. R., Kreis, O., Messmer, D., … Schibli, R. (2017). Dual, site-specific modification of antibodies by using solid-phase immobilized microbial transglutaminase. ChemBioChem, 18(19), 1923-1927. https://doi.org/10.1002/cbic.201700188
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy
Grzmil, M., Seebacher, J., Hess, D., Behe, M., Schibli, R., Moncayo, G., … Hemmings, B. A. (2016). Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy. Cellular Signalling, 28(9), 1412-1421. https://doi.org/10.1016/j.cellsig.2016.06.005
ImmunoPET/MR imaging allows specific detection of <em>Aspergillus fumigatus</em> lung infection in vivo
Rolle, A. M., Hasenberg, M., Thornton, C. R., Solouk-Saran, D., Männ, L., Weski, J., … Wiehr, S. (2016). ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo. Proceedings of the National Academy of Sciences of the United States of America PNAS, 113(8), E1026-E1033. https://doi.org/10.1073/pnas.1518836113