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Structural insight into the stabilization of microtubules by taxanes
Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., … Díaz, J. F. (2023). Structural insight into the stabilization of microtubules by taxanes. eLife, 12, e84791 (35 pp.). https://doi.org/10.7554/elife.84791
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Wranik, M., Weinert, T., Slavov, C., Masini, T., Furrer, A., Gaillard, N., … Standfuss, J. (2023). Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nature Communications, 14(1), 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23
Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, N. M., Mühlethaler, T., Di Martino, R. M. C., Ortega, J. A., Gioia, D., Roy, B., … Cavalli, A. (2022). Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 241, 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
Comprehensive analysis of binding sites in tubulin
Mühlethaler, T., Gioia, D., Prota, A. E., Sharpe, M. E., Cavalli, A., & Steinmetz, M. O. (2021). Comprehensive analysis of binding sites in tubulin. Angewandte Chemie International Edition, 60(24), 13331-13342. https://doi.org/10.1002/anie.202100273
Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Guo, B., Rodriguez-Gabin, A., Prota, A. E., Mühlethaler, T., Zhang, N., Ye, K., … McDaid, H. M. (2020). Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence. Molecular Pharmacology, 98(2), 156-167. https://doi.org/10.1124/mol.119.117457
Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., … Yunes, J. A. (2019). Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia. iScience, 21, 95-109. https://doi.org/10.1016/j.isci.2019.10.003
MAP7 family proteins regulate kinesin-1 recruitment and activation
Hooikaas, P. J., Martin, M., Mühlethaler, T., Kuijntjes, G. J., Peeters, C. A. E., Katrukha, E. A., … Akhmanova, A. (2019). MAP7 family proteins regulate kinesin-1 recruitment and activation. Journal of Cell Biology, 218(4), 1298-1318. https://doi.org/10.1083/jcb.201808065
VISAGE reveals a targetable mitotic spindle vulnerability in cancer cells
Patterson, J. C., Joughin, B. A., Prota, A. E., Mühlethaler, T., Jonas, O. H., Whitman, M. A., … Yaffe, M. B. (2019). VISAGE reveals a targetable mitotic spindle vulnerability in cancer cells. Cell Systems, 9(1), 74-92.e8. https://doi.org/10.1016/j.cels.2019.05.009
Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands
de Asís Balaguer, F., Mühlethaler, T., Estévez-Gallego, J., Calvo, E., Giménez-Abián, J., Risinger, A. L., … Díaz, J. F. (2019). Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands. International Journal of Molecular Sciences, 20(6), 1392 (17 pp.). https://doi.org/10.3390/ijms20061392