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Maytansinol derivatives: side reactions as a chance for new tubulin binders
Marzullo, P., Boiarska, Z., Pérez-Peña, H., Abel, A. C., Álvarez-Bernad, B., Lucena-Agell, D., … Passarella, D. (2022). Maytansinol derivatives: side reactions as a chance for new tubulin binders. Chemistry: A European Journal, 28(2), e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23
Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
Cu<sup>2+</sup> ions modulate the interaction between α-synuclein and lipid membranes
Wang, H., Mörman, C., Sternke-Hoffmann, R., Huang, C. Y., Prota, A., Ma, P., & Luo, J. (2022). Cu2+ ions modulate the interaction between α-synuclein and lipid membranes. Journal of Inorganic Biochemistry, 236, 111945 (10 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111945
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, N. M., Mühlethaler, T., Di Martino, R. M. C., Ortega, J. A., Gioia, D., Roy, B., … Cavalli, A. (2022). Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 241, 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals
Blum, T. B., Housset, D., Clabbers, M. T. B., van Genderen, E., Bacia-Verloop, M., Zander, U., … Abrahams, J. P. (2021). Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals. Acta Crystallographica Section D: Structural Biology, 77, 75-85. https://doi.org/10.1107/S2059798320014540
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
Gaillard, N., Sharma, A., Abbaali, I., Liu, T., Shilliday, F., Cook, A. D., … Steinmetz, M. O. (2021). Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. EMBO Molecular Medicine, 13(11), e13818 (12 pp.). https://doi.org/10.15252/emmm.202013818
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Ijavi, M., Style, R. W., Emmanouilidis, L., Kumar, A., Meier, S. M., Torzynski, A. L., … Dufresne, E. R. (2021). Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method. Soft Matter, 17(6), 1655-1662. https://doi.org/10.1039/d0sm01319f
Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent
Jernigan, F., Branstrom, A., Baird, J. D., Cao, L., Dali, M., Furia, B., … Weetall, M. (2021). Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent. Molecular Cancer Therapeutics, 20(10), 1846-1857. https://doi.org/10.1158/1535-7163.MCT-20-0774
Structure and regulation of the microtubule plus-end tracking protein Kar9
Kumar, A., Meier, S. M., Farcas, A. M., Manatschal, C., Barral, Y., & Steinmetz, M. O. (2021). Structure and regulation of the microtubule plus-end tracking protein Kar9. Structure, 29(11), 1266-1278.e4. https://doi.org/10.1016/j.str.2021.06.012
Versatile microporous polymer-based supports for serial macromolecular crystallography
Martiel, I., Beale, J. H., Karpik, A., Huang, C. Y., Vera, L., Olieric, N., … Padeste, C. (2021). Versatile microporous polymer-based supports for serial macromolecular crystallography. Acta Crystallographica Section D: Structural Biology, 77(9), 1153-1167. https://doi.org/10.1107/S2059798321007324
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Matthew, S., Chen, Q. Y., Ratnayake, R., Fermaintt, C. S., Lucena-Agell, D., Bonato, F., … Luesch, H. (2021). Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proceedings of the National Academy of Sciences of the United States of America PNAS, 118(9), e2021847118 (11 pp.). https://doi.org/10.1073/pnas.2021847118
Comprehensive analysis of binding sites in tubulin
Mühlethaler, T., Gioia, D., Prota, A. E., Sharpe, M. E., Cavalli, A., & Steinmetz, M. O. (2021). Comprehensive analysis of binding sites in tubulin. Angewandte Chemie International Edition, 60(24), 13331-13342. https://doi.org/10.1002/anie.202100273
Centriole length control
Sharma, A., Olieric, N., & Steinmetz, M. O. (2021). Centriole length control. Current Opinion in Structural Biology, 66, 89-95. https://doi.org/10.1016/j.sbi.2020.10.011
Cryo-electron microscopy imaging of Alzheimer's amyloid-beta 42 oligomer displayed on a functionally and structurally relevant scaffold
Wu, J., Blum, T. B., Farrell, D. P., DiMaio, F., Abrahams, J. P., & Luo, J. (2021). Cryo-electron microscopy imaging of Alzheimer's amyloid-beta 42 oligomer displayed on a functionally and structurally relevant scaffold. Angewandte Chemie International Edition, 60(34), 18680-18687. https://doi.org/10.1002/anie.202104497
Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in &lt;em&gt;Streptomyces&lt;/em&gt;
Xiao, X., Willemse, J., Voskamp, P., Li, X., Prota, A. E., Lamers, M., … van Wezel, G. P. (2021). Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces. Open Biology, 11(2), 200409 (14 pp.). https://doi.org/10.1098/rsob.200409
1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure
Yong, C., Devine, S. M., Abel, A. C., Tomlins, S. D., Muthiah, D., Gao, X., … Scammells, P. J. (2021). 1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure. ChemMedChem, 16(18), 2882-2894. https://doi.org/10.1002/cmdc.202100363
The mechanism of kinesin inhibition by kinesin binding protein
Atherton, J., Hummel, J. J. A., Olieric, N., Locke, J., Peña, A., Rosenfeld, S. S., … Moores, C. A. (2020). The mechanism of kinesin inhibition by kinesin binding protein. eLife, 9, e61481 (30 pp.). https://doi.org/10.7554/eLife.61481
Structural model for differential cap maturation at growing microtubule ends
Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., … Oliva, M. A. (2020). Structural model for differential cap maturation at growing microtubule ends. eLife, 9, e50155 (26 pp.). https://doi.org/10.7554/eLife.50155
 

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