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  • (-) PSI Groups = 2313 Biomolecular Complexes
  • (-) Keywords = microtubules
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Maytansinol functionalization: towards useful probes for studying microtubule dynamics
Boiarska, Z., Pérez-Peña, H., Abel, A. C., Marzullo, P., Álvarez-Bernad, B., Bonato, F., … Passarella, D. (2023). Maytansinol functionalization: towards useful probes for studying microtubule dynamics. Chemistry: A European Journal, 29(5), e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431
Computational approaches to the rational design of tubulin-targeting agents
Pérez-Peña, H., Abel, A. C., Shevelev, M., Prota, A. E., Pieraccini, S., & Horvath, D. (2023). Computational approaches to the rational design of tubulin-targeting agents. Biomolecules, 13(2), 285 (35 pp.). https://doi.org/10.3390/biom13020285
Maytansinol derivatives: side reactions as a chance for new tubulin binders
Marzullo, P., Boiarska, Z., Pérez-Peña, H., Abel, A. C., Álvarez-Bernad, B., Lucena-Agell, D., … Passarella, D. (2022). Maytansinol derivatives: side reactions as a chance for new tubulin binders. Chemistry: A European Journal, 28(2), e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
Gaillard, N., Sharma, A., Abbaali, I., Liu, T., Shilliday, F., Cook, A. D., … Steinmetz, M. O. (2021). Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. EMBO Molecular Medicine, 13(11), e13818 (12 pp.). https://doi.org/10.15252/emmm.202013818
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Matthew, S., Chen, Q. Y., Ratnayake, R., Fermaintt, C. S., Lucena-Agell, D., Bonato, F., … Luesch, H. (2021). Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proceedings of the National Academy of Sciences of the United States of America PNAS, 118(9), e2021847118 (11 pp.). https://doi.org/10.1073/pnas.2021847118
Comprehensive analysis of binding sites in tubulin
Mühlethaler, T., Gioia, D., Prota, A. E., Sharpe, M. E., Cavalli, A., & Steinmetz, M. O. (2021). Comprehensive analysis of binding sites in tubulin. Angewandte Chemie International Edition, 60(24), 13331-13342. https://doi.org/10.1002/anie.202100273
Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands
de Asís Balaguer, F., Mühlethaler, T., Estévez-Gallego, J., Calvo, E., Giménez-Abián, J., Risinger, A. L., … Díaz, J. F. (2019). Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands. International Journal of Molecular Sciences, 20(6), 1392 (17 pp.). https://doi.org/10.3390/ijms20061392
Structural basis of microtubule stabilization by discodermolide
Prota, A. E., Bargsten, K., Redondo-Horcajo, M., Smith, A. B., Yang, C. P. H., McDaid, H. M., … Steinmetz, M. O. (2017). Structural basis of microtubule stabilization by discodermolide. ChemBioChem, 18(10), 905-909. https://doi.org/10.1002/cbic.201600696
Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
Sharma, A., Sáez-Calvo, G., Olieric, N., de Asís Balaguer, F., Barasoain, I., Lamberth, C., … Steinmetz, M. O. (2017). Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin. International Journal of Molecular Sciences, 18(7), 1336 (11 pp.). https://doi.org/10.3390/ijms18071336