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Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome
Hempelmann, A., Hartleb, L., van Straaten, M., Hashemi, H., Zeelen, J. P., Bongers, K., … Jones, N. G. (2021). Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome. Cell Reports, 37(5), 109923 (25 pp.). https://doi.org/10.1016/j.celrep.2021.109923
Pulmonary acini exhibit complex changes during postnatal rat lung development
Haberthür, D., Yao, E., Barré, S. F., Cremona, T. P., Tschanz, S. A., & Schittny, J. C. (2021). Pulmonary acini exhibit complex changes during postnatal rat lung development. PLoS One, 16(11), e0257349 (20 pp.). https://doi.org/10.1371/journal.pone.0257349
Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex
Chicano, T. M., Dietrich, L., de Almeida, N. M., Akram, M., Hartmann, E., Leidreiter, F., … Barends, T. R. M. (2021). Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex. Nature Microbiology, 6(9), 1129-1139. https://doi.org/10.1038/s41564-021-00934-8
Identification of clinical candidate M2698, a dual p70S6K and akt inhibitor, for treatment of PAM pathway-altered cancers
DeSelm, L., Huck, B., Lan, R., Neagu, C., Potnick, J., Xiao, Y., … Goutopoulos, A. (2021). Identification of clinical candidate M2698, a dual p70S6K and akt inhibitor, for treatment of PAM pathway-altered cancers. Journal of Medicinal Chemistry, 64(19), 14603-14619. https://doi.org/10.1021/acs.jmedchem.1c01087
Electric field control of the magnetic weyl fermion in an epitaxial SrRuO<sub>3</sub> (111) thin film
Lin, W., Liu, L., Liu, Q., Li, L., Shu, X., Li, C., … Chen, J. (2021). Electric field control of the magnetic weyl fermion in an epitaxial SrRuO3 (111) thin film. Advanced Materials, 33(36), 2101316 (8 pp.). https://doi.org/10.1002/adma.202101316
Structure-function analysis of pectate lyase Pel3 reveals essential facets of protein recognition by the bacterial type 2 secretion system
Pineau, C., Guschinskaya, N., Gonçalves, I. R., Ruaudel, F., Robert, X., Gouet, P., … Shevchik, V. E. (2021). Structure-function analysis of pectate lyase Pel3 reveals essential facets of protein recognition by the bacterial type 2 secretion system. Journal of Biological Chemistry, 296, 100305 (12 pp.). https://doi.org/10.1016/j.jbc.2021.100305
Structure and ion-release mechanism of P<sub>IB-4</sub>-type ATPases
Grønberg, C., Hu, Q., Mahato, D. R., Longhin, E., Salustros, N., Duelli, A., … Gourdon, P. (2021). Structure and ion-release mechanism of PIB-4-type ATPases. eLife, 10, e73124 (21 pp.). https://doi.org/10.7554/eLife.73124
Mapping orbital-resolved magnetism in single lanthanide atoms
Singha, A., Sostina, D., Wolf, C., Ahmed, S. L., Krylov, D., Colazzo, L., … Donati, F. (2021). Mapping orbital-resolved magnetism in single lanthanide atoms. ACS Nano, 15(10), 16162-16171. https://doi.org/10.1021/acsnano.1c05026
Discovery of a new series of PI3K-δ inhibitors from virtual screening
Fradera, X., Deng, Q., Achab, A., Garcia, Y., Kattar, S. D., McGowan, M. A., … Katz, J. D. (2021). Discovery of a new series of PI3K-δ inhibitors from virtual screening. Bioorganic and Medicinal Chemistry Letters, 42, 128046 (5 pp.). https://doi.org/10.1016/j.bmcl.2021.128046
Development of a selective dual discoidin domain receptor (DDR)/p38 kinase chemical probe
Röhm, S., Berger, B. T., Schröder, M., Chatterjee, D., Mathea, S., Joerger, A. C., … Knapp, S. (2021). Development of a selective dual discoidin domain receptor (DDR)/p38 kinase chemical probe. Journal of Medicinal Chemistry, 64(18), 13451-13474. https://doi.org/10.1021/acs.jmedchem.1c00868
Ultrastructure and in-situ chemical characterization of intracellular granules of embryo-like fossils from the early Ediacaran Weng'an biota
Sun, W., Yin, Z., Liu, P., Donoghue, P. C. J., Li, J., & Zhu, M. (2021). Ultrastructure and in-situ chemical characterization of intracellular granules of embryo-like fossils from the early Ediacaran Weng'an biota. PalZ, 95(4), 611-621. https://doi.org/10.1007/s12542-021-00597-0
Mcsb forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
Hajdusits, B., Suskiewicz, M. J., Hundt, N., Meinhart, A., Kurzbauer, R., Leodolter, J., … Clausen, T. (2021). Mcsb forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. eLife, 10, e63505 (24 pp.). https://doi.org/10.7554/eLife.63505
Structure-based optimization and characterization of macrocyclic Zika virus NS2B-NS3 protease inhibitors
Huber, S., Braun, N. J., Schmacke, L. C., Quek, J. P., Murra, R., Bender, D., … Steinmetzer, T. (2021). Structure-based optimization and characterization of macrocyclic Zika virus NS2B-NS3 protease inhibitors. Journal of Medicinal Chemistry, 65(9), 6555-6572. https://doi.org/10.1021/acs.jmedchem.1c01860
Insights into the structure and RNA-binding specificity of <em>Caenorhabditis elegans</em> Dicer-related helicase 3 (DRH-3)
Li, K., Zheng, J., Wirawan, M., Trinh, N. M., Fedorova, O., Griffin, P. R., … Luo, D. (2021). Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3). Nucleic Acids Research, 49(17), 9978-9991. https://doi.org/10.1093/nar/gkab712
Structure-based design of dual partial peroxisome proliferator-activated receptor <em>γ</em> agonists/soluble epoxide hydrolase inhibitors
Lillich, F. F., Willems, S., Ni, X., Kilu, W., Borkowsky, C., Brodsky, M., … Proschak, E. (2021). Structure-based design of dual partial peroxisome proliferator-activated receptor γ agonists/soluble epoxide hydrolase inhibitors. Journal of Medicinal Chemistry, 64(23), 17259-17276. https://doi.org/10.1021/acs.jmedchem.1c01331
Structural basis of cyclic 1,3-diene forming acyl-coenzyme a dehydrogenases
Kung, J. W., Meier, A. K., Willistein, M., Weidenweber, S., Demmer, U., Ermler, U., & Boll, M. (2021). Structural basis of cyclic 1,3-diene forming acyl-coenzyme a dehydrogenases. ChemBioChem, 22(22), 3173-3177. https://doi.org/10.1002/cbic.202100421
Imaging autotaxin in vivo with <sup>18</sup>F-labeled positron emission tomography ligands
Deng, X., Salgado-Polo, F., Shao, T., Xiao, Z., Van, R., Chen, J., … Liang, S. H. (2021). Imaging autotaxin in vivo with 18F-labeled positron emission tomography ligands. Journal of Medicinal Chemistry, 64(20), 15053-15068. https://doi.org/10.1021/acs.jmedchem.1c00913
Ultrafast photo-ion probing of the ring-opening process in trans-stilbene oxide
Robinson, M. S., Niebuhr, M., Lever, F., Mayer, D., Metje, J., & Gühr, M. (2021). Ultrafast photo-ion probing of the ring-opening process in trans-stilbene oxide. Chemistry: A European Journal, 27(44), 11418-11427. https://doi.org/10.1002/chem.202101343
Effects of Ti substitution for Zr on the electrochemical characteristics and structure of AB<sub>2</sub>-type Laves-phase alloys as metal hydride anodes
Wan, C. B., Denys, R. V., & Yartys, V. A. (2021). Effects of Ti substitution for Zr on the electrochemical characteristics and structure of AB2-type Laves-phase alloys as metal hydride anodes. Journal of Alloys and Compounds, 889, 161655 (9 pp.). https://doi.org/10.1016/j.jallcom.2021.161655
On the crystal structure thermal evolution of formamidinium lead tribromide, CH(NH<sub>2</sub>)<sub>2</sub>PbBr<sub>3</sub>
Abia, C., López, C. A., Álvarez-Galván, M. C., Canadillas-Delgado, L., Fernández-Díaz, M. T., & Alonso, J. A. (2021). On the crystal structure thermal evolution of formamidinium lead tribromide, CH(NH2)2PbBr3. Journal of Materials Chemistry C, 9(47), 17003-17011. https://doi.org/10.1039/d1tc04642j
 

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