| Validation of a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets
Ohta, A., Tanada, M., Shinohara, S., Morita, Y., Nakano, K., Yamagishi, Y., … Iikura, H. (2023). Validation of a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets. Journal of the American Chemical Society, 145(44), 24035-24051. https://doi.org/10.1021/jacs.3c07145 |
| Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
O’Dea, R., Kazi, N., Hoffmann-Benito, A., Zhao, Z., Recknagel, S., Wendrich, K., … Gersch, M. (2023). Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nature Chemical Biology, 19(11), 1394-1405. https://doi.org/10.1038/s41589-023-01388-1 |
| Design and preclinical characterization program toward Asundexian (BAY 2433334), an oral factor XIa inhibitor for the prevention and treatment of thromboembolic disorders
Roehrig, S., Ackerstaff, J., Jiménez Núñez, E., Teller, H., Ellerbrock, P., Meier, K., … Hillisch, A. (2023). Design and preclinical characterization program toward Asundexian (BAY 2433334), an oral factor XIa inhibitor for the prevention and treatment of thromboembolic disorders. Journal of Medicinal Chemistry, 66(17), 12203-12224. https://doi.org/10.1021/acs.jmedchem.3c00795 |
| Structure of a volume-regulated heteromeric LRRC8A/C channel
Rutz, S., Deneka, D., Dittmann, A., Sawicka, M., & Dutzler, R. (2023). Structure of a volume-regulated heteromeric LRRC8A/C channel. Nature Structural and Molecular Biology, 30, 52-61. https://doi.org/10.1038/s41594-022-00899-0 |
| Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding
Schmeing, S., Amrahova, G., Bigler, K., Chang, J. Y., Openy, J., Pal, S., … 't Hart, P. (2023). Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chemical Science, 14(31), 8269-8278. https://doi.org/10.1039/d3sc00985h |
| MSC-1186, a highly selective Pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core
Schröder, M., Leiendecker, M., Grädler, U., Braun, J., Blum, A., Wanior, M., … Heinrich, T. (2023). MSC-1186, a highly selective Pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core. Journal of Medicinal Chemistry, 66(1), 837-854. https://doi.org/10.1021/acs.jmedchem.2c01705 |
| Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA
Selim, K. A., Haffner, M., Mantovani, O., Albrecht, R., Zhu, H., Hagemann, M., … Hartmann, M. D. (2023). Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA. Proceedings of the National Academy of Sciences of the United States of America PNAS, 120(8), e2205882120 (11 pp.). https://doi.org/10.1073/pnas.2205882120 |
| Optimization of a class of dihydrobenzofurane analogs toward orally efficacious YAP-TEAD protein-protein interaction inhibitors
Sellner, H., Chapeau, E., Furet, P., Voegtle, M., Salem, B., Le Douget, M., … Soldermann, N. (2023). Optimization of a class of dihydrobenzofurane analogs toward orally efficacious YAP-TEAD protein-protein interaction inhibitors. ChemMedChem, 18(11), e202300051 (23 pp.). https://doi.org/10.1002/cmdc.202300051 |
| Revision of the absolute configurations of chelocardin and amidochelocardin
Sikandar, A., Popoff, A., Jumde, R. P., Mándi, A., Kaur, A., Elgaher, W. A. M., … Müller, R. (2023). Revision of the absolute configurations of chelocardin and amidochelocardin. Angewandte Chemie International Edition, 62(40), e202306437 (5 pp.). https://doi.org/10.1002/anie.202306437 |
| SDU - software for high-throughput automated data collection at the Swiss Light Source
Smith, K. M. L., Panepucci, E., Kaminski, J. W., Aumonier, S., Huang, C. Y., Eris, D., … Wojdyla, J. A. (2023). SDU - software for high-throughput automated data collection at the Swiss Light Source. Journal of Synchrotron Radiation, 30, 538-545. https://doi.org/10.1107/S1600577523002631 |
| Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells
Spiller, L., Manjula, R., Leissing, F., Basquin, J., Bourilhon, P., Sinitski, D., … Lolis, E. (2023). Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells. Science Signaling, 16(812), eadg2621 (18 pp.). https://doi.org/10.1126/scisignal.adg2621 |
| Fast fragment and compound screening pipeline at the Swiss Light Source
Stegmann, D. P., Steuber, J., Fritz, G., Wojdyla, J. A., & Sharpe, M. E. (2023). Fast fragment and compound screening pipeline at the Swiss Light Source. Methods in enzymology: Vol. 690. (pp. 235-284). https://doi.org/10.1016/bs.mie.2023.08.005 |
| Leveraging ligand affinity and properties: discovery of novel benzamide-type cereblon binders for the design of PROTACs
Steinebach, C., Bricelj, A., Murgai, A., Sosič, I., Bischof, L., Ng, Y. L. D., … Hartmann, M. D. (2023). Leveraging ligand affinity and properties: discovery of novel benzamide-type cereblon binders for the design of PROTACs. Journal of Medicinal Chemistry, 66(21), 14513-14543. https://doi.org/10.1021/acs.jmedchem.3c00851 |
| Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase**
Stephan, P., Langley, C., Winkler, D., Basquin, J., Caputi, L., O'Connor, S. E., & Kries, H. (2023). Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase**. Angewandte Chemie International Edition, 62(35), e202304843 (6 pp.). https://doi.org/10.1002/anie.202304843 |
| Discovery of amino alcohols as highly potent, selective, and orally efficacious inhibitors of leukotriene A4 hydrolase
Thoma, G., Markert, C., Lueoend, R., Miltz, W., Spanka, C., Bollbuck, B., … Röhn, T. A. (2023). Discovery of amino alcohols as highly potent, selective, and orally efficacious inhibitors of leukotriene A4 hydrolase. European Journal of Medicinal Chemistry, 66, 16410-16425. https://doi.org/10.1021/acs.jmedchem.3c01866 |
| Discovery of quinazoline HPK1 inhibitors with high cellular potency
Toure, M., Johnson, T., Li, B., Schmidt, R., Ma, H., Neagu, C., … Sherer, B. (2023). Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorganic and Medicinal Chemistry, 92, 117423 (16 pp.). https://doi.org/10.1016/j.bmc.2023.117423 |
| Fluorescent sensors for imaging of interstitial calcium
Valiente-Gabioud, A. A., Garteizgogeascoa Suñer, I., Idziak, A., Fabritius, A., Basquin, J., Angibaud, J., … Griesbeck, O. (2023). Fluorescent sensors for imaging of interstitial calcium. Nature Communications, 14(1), 6220 (15 pp.). https://doi.org/10.1038/s41467-023-41928-w |
| Discovery of potent, orally bioavailable, tricyclic NLRP3 inhibitors
Velcicky, J., Janser, P., Gommermann, N., Brenneisen, S., Ilic, S., Vangrevelinghe, E., … Mackay, A. (2023). Discovery of potent, orally bioavailable, tricyclic NLRP3 inhibitors. Journal of Medicinal Chemistry, 67, 1544-1562. https://doi.org/10.1021/acs.jmedchem.3c02098 |
| Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field
Vulpetti, A., Holzer, P., Schmiedeberg, N., Imbach-Weese, P., Pissot-Soldermann, C., Hollingworth, G. J., … Renatus, M. (2023). Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field. ACS Medicinal Chemistry Letters, 14(7), 949-954. https://doi.org/10.1021/acsmedchemlett.3c00104 |
| Native semisynthesis of isopeptide-linked substrates for specificity analysis of deubiquitinases and Ubl proteases
Zhao, Z., O’Dea, R., Wendrich, K., Kazi, N., & Gersch, M. (2023). Native semisynthesis of isopeptide-linked substrates for specificity analysis of deubiquitinases and Ubl proteases. Journal of the American Chemical Society, 145(38), 20801-20812. https://doi.org/10.1021/jacs.3c04062 |
