Active Filters

  • (-) Full Text ≠ Open Access
  • (-) Publication Status = Published
  • (-) Collection ≠ info:fedora/psi:publications
Search Results 1 - 20 of 3,787

Pages

  • RSS Feed
Select Page
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Abrami, L., Audagnotto, M., Ho, S., Marcaida, M. J., Mesquita, F. S., Anwar, M. U., … van der Goot, F. G. (2021). Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nature Chemical Biology, 17(4), 438-447. https://doi.org/10.1038/s41589-021-00753-2
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
Akaki, T., Bessho, Y., Ito, T., Fujioka, S., Ubukata, M., Mori, G., … Adachi, T. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic and Medicinal Chemistry, 44, 116283 (15 pp.). https://doi.org/10.1016/j.bmc.2021.116283
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Bao, C., Bajrami, B., Marcotte, D. J., Chodaparambil, J. V., Kerns, H. M., Henderson, J., … Dillon, G. M. (2021). Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms. Cellular and Molecular Neurobiology, 41, 669-685. https://doi.org/10.1007/s10571-020-00875-6
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
Basler, S., Studer, S., Zou, Y., Mori, T., Ota, Y., Camus, A., … Hilvert, D. (2021). Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nature Chemistry, 13(3), 231-235. https://doi.org/10.1038/s41557-020-00628-4
Structure-based design of high-affinity macrocyclic FKBP51 inhibitors
Bauder, M., Meyners, C., Purder, P. L., Merz, S., Sugiarto, W. O., Voll, A. M., … Hausch, F. (2021). Structure-based design of high-affinity macrocyclic FKBP51 inhibitors. Journal of Medicinal Chemistry, 64(6), 3320-3349. https://doi.org/10.1021/acs.jmedchem.0c02195
<em>In vitro</em> reconstitution of a five-step pathway for bacterial ergothioneine catabolism
Beliaeva, M. A., Leisinger, F., & Seebeck, F. P. (2021). In vitro reconstitution of a five-step pathway for bacterial ergothioneine catabolism. ACS Chemical Biology, 16(2), 397-403. https://doi.org/10.1021/acschembio.0c00968
Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization
Benz, J., Rufer, A. C., Huber, S., Ehler, A., Hug, M., Topp, A., … Rodríguez Sarmiento, R. M. (2021). Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization. Angewandte Chemie International Edition, 60(10), 5436-5442. https://doi.org/10.1002/anie.202013890
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., … Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chemical Biology, 28(5), 686-698. https://doi.org/10.1016/j.chembiol.2021.01.003
Evaluation of scanning transmission X-ray microscopy at the Mn L<sub>2,3</sub>-edges as a potential probe for manganese redox state in natural silicates
Bourdelle, F., Lloret, E., Durand, C., & Airaghi, L. (2021). Evaluation of scanning transmission X-ray microscopy at the Mn L2,3-edges as a potential probe for manganese redox state in natural silicates. Physics and Chemistry of Minerals, 48, 18 (12 pp.). https://doi.org/10.1007/s00269-021-01142-w
Architecture of the membrane-bound cytochrome c heme lyase CcmF
Brausemann, A., Zhang, L., Ilcu, L., & Einsle, O. (2021). Architecture of the membrane-bound cytochrome c heme lyase CcmF. Nature Chemical Biology, 17(7), 800-805. https://doi.org/10.1038/s41589-021-00793-8
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors
Brullo, C., Rapetti, F., Abbate, S., Prosdocimi, T., Torretta, A., Semrau, M., … Bruno, O. (2021). Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors. European Journal of Medicinal Chemistry, 223, 113638 (13 pp.). https://doi.org/10.1016/j.ejmech.2021.113638
Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models
Buchstaller, H. P., Anlauf, U., Dorsch, D., Kögler, S., Kuhn, D., Lehmann, M., … Esdar, C. (2021). Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models. Journal of Medicinal Chemistry, 64(14), 10371-10392. https://doi.org/10.1021/acs.jmedchem.1c00800
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
Böhm, R., Imseng, S., Jakob, R. P., Hall, M. N., Maier, T., & Hiller, S. (2021). The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Molecular Cell, 81(11), 2403-2416. https://doi.org/10.1016/j.molcel.2021.03.031
Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis
Christoffel, F., Igareta, N. V., Pellizzoni, M. M., Tiessler-Sala, L., Lozhkin, B., Spiess, D. C., … Ward, T. R. (2021). Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis. Nature Catalysis, 4(8), 643-653. https://doi.org/10.1038/s41929-021-00651-9
Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
Conrady, M. C., Suarez, I., Gogl, G., Frecot, D. I., Bonhoure, A., Kostmann, C., … Simon, C. (2021). Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation. Journal of Virology, 95(2), e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
Sweet drugs for bad bugs: a glycomimetic strategy against the DC-SIGN-mediated dissemination of SARS-CoV-2
Cramer, J., Lakkaichi, A., Aliu, B., Jakob, R. P., Klein, S., Cattaneo, I., … Ernst, B. (2021). Sweet drugs for bad bugs: a glycomimetic strategy against the DC-SIGN-mediated dissemination of SARS-CoV-2. Journal of the American Chemical Society, 143(42), 17465-17478. https://doi.org/10.1021/jacs.1c06778
Multi-technique study of precipitation in the near-fusion boundary region of an aged narrow-gap dissimilar metal weld
De Geuser, F., Akhatova, A., Danoix, F., Robaut, F., Yescas, M., Roch, F., … Van Landeghem, H. P. (2021). Multi-technique study of precipitation in the near-fusion boundary region of an aged narrow-gap dissimilar metal weld. Materialia, 16, 101106 (11 pp.). https://doi.org/10.1016/j.mtla.2021.101106
Structure–function dataset reveals environment effects within a fluorescent protein model system
De Zitter, E., Hugelier, S., Duwé, S., Vandenberg, W., Tebo, A. G., Van Meervelt, L., & Dedecker, P. (2021). Structure–function dataset reveals environment effects within a fluorescent protein model system. Angewandte Chemie International Edition, 60(18), 10073-10081. https://doi.org/10.1002/anie.202015201
Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition
Dekker, C., Mattes, H., Wright, M., Boettcher, A., Hinniger, A., Hughes, N., … Farady, C. J. (2021). Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition. Journal of Molecular Biology, 433(24), 167309 (11 pp.). https://doi.org/10.1016/j.jmb.2021.167309
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
Dimovasili, C., Fadouloglou, V. E., Kefala, A., Providaki, M., Kotsifaki, D., Kanavouras, K., … Kokkinidis, M. (2021). Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15296
 

Pages