| Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778 |
| Development of potent and selective monoacylglycerol lipase inhibitors. SARs, structural analysis, and biological characterization
Butini, S., Grether, U., Jung, K. M., Ligresti, A., Allarà, M., Postmus, A. G. J., … Campiani, G. (2024). Development of potent and selective monoacylglycerol lipase inhibitors. SARs, structural analysis, and biological characterization. Journal of Medicinal Chemistry, 67(3), 1758-1782. https://doi.org/10.1021/acs.jmedchem.3c01278 |
| Recording physiological history of cells with chemical labeling
Huppertz, M. C., Wilhelm, J., Grenier, V., Schneider, M. W., Falt, T., Porzberg, N., … Johnsson, K. (2024). Recording physiological history of cells with chemical labeling. Science, 383(6685), 890-897. https://doi.org/10.1126/science.adg0812 |
| Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation
Kageji, H., Momose, T., Nagamoto, Y., Togashi, N., Yasumatsu, I., Nishikawa, Y., … Naito, H. (2024). Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. Bioorganic and Medicinal Chemistry Letters, 98, 129575 (7 pp.). https://doi.org/10.1016/j.bmcl.2023.129575 |
| Microsecond timescale conformational dynamics of a small-molecule ligand within the active site of a protein
Kotschy, J., Söldner, B., Singh, H., Vasa, S. K., & Linser, R. (2024). Microsecond timescale conformational dynamics of a small-molecule ligand within the active site of a protein. Angewandte Chemie International Edition, 63(5), e202313947 (6 pp.). https://doi.org/10.1002/anie.202313947 |
| Design principles for cyclin K molecular glue degraders
Kozicka, Z., Suchyta, D. J., Focht, V., Kempf, G., Petzold, G., Jentzsch, M., … Thomä, N. H. (2024). Design principles for cyclin K molecular glue degraders. Nature Chemical Biology, 20(1), 93-102. https://doi.org/10.1038/s41589-023-01409-z |
| BAY-9835: discovery of the first orally bioavailable ADAMTS7 inhibitor
Meibom, D., Wasnaire, P., Beyer, K., Broehl, A., Cancho-Grande, Y., Elowe, N., … Zubov, D. (2024). BAY-9835: discovery of the first orally bioavailable ADAMTS7 inhibitor. Journal of Medicinal Chemistry, 67(4), 2907-2940. https://doi.org/10.1021/acs.jmedchem.3c02036 |
| <em>N</em>-cyanopiperazines as specific covalent inhibitors of the deubiquitinating enzyme UCHL1
Schmidt, M., Grethe, C., Recknagel, S., Kipka, G. M., Klink, N., & Gersch, M. (2024). N-cyanopiperazines as specific covalent inhibitors of the deubiquitinating enzyme UCHL1. Angewandte Chemie International Edition, 63(12), e202318849 (10 pp.). https://doi.org/10.1002/anie.202318849 |
| Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
Teuber, A., Schulz, T., Fletcher, B. S., Gontla, R., Mühlenberg, T., Zischinsky, M. L., … Rauh, D. (2024). Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nature Communications, 15(1), 63 (11 pp.). https://doi.org/10.1038/s41467-023-44376-8 |
| Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis
Abe-Sato, K., Tabuse, H., Kanazawa, H., Kamitani, M., Endo, M., Tokura, S., … Oka, Y. (2023). Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis. Journal of Medicinal Chemistry, 66(21), 14653-14668. https://doi.org/10.1021/acs.jmedchem.3c01166 |
| Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., … Koehnke, J. (2023). Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), 560-568. https://doi.org/10.1038/s41557-023-01153-w |
| Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases
Alper, P., Betschart, C., André, C., Boulay, T., Cheng, D., Deane, J., … Michellys, P. Y. (2023). Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases. ACS Medicinal Chemistry Letters, 14(8), 1054-1062. https://doi.org/10.1021/acsmedchemlett.3c00136 |
| Structure of <em>Leishmania donovani</em> 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment
Berneburg, I., Stumpf, M., Velten, A. S., Rahlfs, S., Przyborski, J., Becker, K., & Fritz-Wolf, K. (2023). Structure of Leishmania donovani 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment. International Journal of Molecular Sciences, 24(10), 8615 (20 pp.). https://doi.org/10.3390/ijms24108615 |
| Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors
Blum, A., Dorsch, D., Linde, N., Brandstetter, S., Buchstaller, H. P., Busch, M., … Esdar, C. (2023). Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors. Journal of Medicinal Chemistry, 66(4), 2386-2395. https://doi.org/10.1021/acs.jmedchem.2c00851 |
| Se-MAG is a convenient additive for experimental phasing and structure determination of membrane proteins crystallised by the lipid cubic phase (in meso) method
Boland, C., Huang, C. Y., Shanker Kaki, S., Wang, M., Olieric, V., & Caffrey, M. (2023). Se-MAG is a convenient additive for experimental phasing and structure determination of membrane proteins crystallised by the lipid cubic phase (in meso) method. Crystals, 13(9), 1402 (20 pp.). https://doi.org/10.3390/cryst13091402 |
| Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2023). Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1125-1242. https://doi.org/10.1021/acs.jmedchem.3c01714 |
| Discovery of cycloalkyl[<em>c</em>]thiophenes as novel scaffolds for hypoxia-inducible factor-2<em>α</em> inhibitors
Buchstaller, H. P., Sala-Hojman, A., Leiendecker, M., Albers, J., Anlauf, U., Berges, N., … Zarębski, A. (2023). Discovery of cycloalkyl[c]thiophenes as novel scaffolds for hypoxia-inducible factor-2α inhibitors. Journal of Medicinal Chemistry, 66(13), 8666-8686. https://doi.org/10.1021/acs.jmedchem.3c00332 |
| FRAGTORY: pharmacophore-focused design, synthesis, and evaluation of an sp<sup>3</sup>-enriched fragment library
Bührmann, M., Kallepu, S., Warmuth, J. D., Wiese, J. N., Ehrt, C., Vatheuer, H., … Rauh, D. (2023). FRAGTORY: pharmacophore-focused design, synthesis, and evaluation of an sp3-enriched fragment library. Journal of Medicinal Chemistry, 66(9), 6297-6314. https://doi.org/10.1021/acs.jmedchem.3c00187 |
| Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity
Chen, X. R., Poudel, L., Hong, Z., Johnen, P., Katti, S., Tripathi, A., … Igumenova, T. I. (2023). Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. Journal of Biological Chemistry, 299(2), 102861 (21 pp.). https://doi.org/10.1016/j.jbc.2022.102861 |
| Crystal structure of adenosine A<sub>2A</sub> receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction
Claff, T., Schlegel, J. G., Voss, J. H., Vaaßen, V. J., Weiße, R. H., Cheng, R. K. Y., … Müller, C. E. (2023). Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Communications Chemistry, 6(1), 106 (10 pp.). https://doi.org/10.1038/s42004-023-00894-6 |