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Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778
PROTACs targeting BRM (SMARCA2) afford selective <em>In vivo</em> degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
Berlin, M., Cantley, J., Bookbinder, M., Bortolon, E., Broccatelli, F., Cadelina, G., … Dragovich, P. S. (2024). PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models. Journal of Medicinal Chemistry, 67, 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
Development of potent and selective monoacylglycerol lipase inhibitors. SARs, structural analysis, and biological characterization
Butini, S., Grether, U., Jung, K. M., Ligresti, A., Allarà, M., Postmus, A. G. J., … Campiani, G. (2024). Development of potent and selective monoacylglycerol lipase inhibitors. SARs, structural analysis, and biological characterization. Journal of Medicinal Chemistry, 67(3), 1758-1782. https://doi.org/10.1021/acs.jmedchem.3c01278
Biochemical and structural characterization of a class A <em>β</em>-lactamase from <em>Nocardia cyriacigeorgica</em>
Feuillard, J., Couston, J., Benito, Y., Hodille, E., Dumitrescu, O., & Blaise, M. (2024). Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 80, 13-21. https://doi.org/10.1107/S2053230X23010671
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Fu, C., Liu, Y., Walt, C., Rasheed, S., Bader, C. D., Lukat, P., … Müller, R. (2024). Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature Communications, 15(1), 791 (13 pp.). https://doi.org/10.1038/s41467-024-44953-5
Ym1 protein crystals promote type 2 immunity
Heyndrickx, I., Deswarte, K., Verstraete, K., Verschueren, K. H. G., Smole, U., Aegerter, H., … Lambrecht, B. N. (2024). Ym1 protein crystals promote type 2 immunity. eLife, 12, RP90676 (17 pp.). https://doi.org/10.7554/eLife.90676
Structure–function relationships underpin disulfide loop cleavage-dependent activation of <em>Legionella pneumophila</em> lysophospholipase A PlaA
Hiller, M., Diwo, M., Wamp, S., Gutsmann, T., Lang, C., Blankenfeldt, W., & Flieger, A. (2024). Structure–function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular Microbiology, 121(3), 497-512. https://doi.org/10.1111/mmi.15201
Recording physiological history of cells with chemical labeling
Huppertz, M. C., Wilhelm, J., Grenier, V., Schneider, M. W., Falt, T., Porzberg, N., … Johnsson, K. (2024). Recording physiological history of cells with chemical labeling. Science, 383(6685), 890-897. https://doi.org/10.1126/science.adg0812
Structure of <em>Staphylococcus aureus </em>ClpP bound to the covalent active-site inhibitor cystargolide A
Illigmann, A., Vielberg, M. T., Lakemeyer, M., Wolf, F., Dema, T., Stange, P., … Brötz-Oesterhelt, H. (2024). Structure of Staphylococcus aureus ClpP bound to the covalent active-site inhibitor cystargolide A. Angewandte Chemie International Edition, 63(3), e202314028 (10 pp.). https://doi.org/10.1002/anie.202314028
Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1), 462-473. https://doi.org/10.1093/nar/gkad1102
Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation
Kageji, H., Momose, T., Nagamoto, Y., Togashi, N., Yasumatsu, I., Nishikawa, Y., … Naito, H. (2024). Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. Bioorganic and Medicinal Chemistry Letters, 98, 129575 (7 pp.). https://doi.org/10.1016/j.bmcl.2023.129575
Microsecond timescale conformational dynamics of a small-molecule ligand within the active site of a protein
Kotschy, J., Söldner, B., Singh, H., Vasa, S. K., & Linser, R. (2024). Microsecond timescale conformational dynamics of a small-molecule ligand within the active site of a protein. Angewandte Chemie International Edition, 63(5), e202313947 (6 pp.). https://doi.org/10.1002/anie.202313947
Design principles for cyclin K molecular glue degraders
Kozicka, Z., Suchyta, D. J., Focht, V., Kempf, G., Petzold, G., Jentzsch, M., … Thomä, N. H. (2024). Design principles for cyclin K molecular glue degraders. Nature Chemical Biology, 20(1), 93-102. https://doi.org/10.1038/s41589-023-01409-z
Photosensitization enables Pauson-Khand-type reactions with nitrenes
Li, F., Zhu, W. F., Empel, C., Datsenko, O., Kumar, A., Xu, Y., … Koenigs, R. M. (2024). Photosensitization enables Pauson-Khand-type reactions with nitrenes. Science, 383(6682), 498-503. https://doi.org/10.1126/science.adm8095
BAY-9835: discovery of the first orally bioavailable ADAMTS7 inhibitor
Meibom, D., Wasnaire, P., Beyer, K., Broehl, A., Cancho-Grande, Y., Elowe, N., … Zubov, D. (2024). BAY-9835: discovery of the first orally bioavailable ADAMTS7 inhibitor. Journal of Medicinal Chemistry, 67(4), 2907-2940. https://doi.org/10.1021/acs.jmedchem.3c02036
Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex
Meinhold, S., Zdanowicz, R., Giese, C., & Glockshuber, R. (2024). Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex. Science Advances, 10(6), eadj6358 (17 pp.). https://doi.org/10.1126/sciadv.adj6358
Optical control of proteasomal protein degradation with a photoswitchable lipopeptide
Morstein, J., Amatuni, A., Shuster, A., Kuttenlochner, W., Ko, T., Abegg, D., … Trauner, D. H. (2024). Optical control of proteasomal protein degradation with a photoswitchable lipopeptide. Angewandte Chemie International Edition, 63(8), e202314791 (7 pp.). https://doi.org/10.1002/anie.202314791
Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations
Müller, M. C., Lemaire, O. N., Kurth, J. M., Welte, C. U., & Wagner, T. (2024). Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Communications Biology, 7(1), 111. https://doi.org/10.1038/s42003-023-05726-w
Enzyme-catalyzed oxidative degradation of ergothioneine
Nalivaiko, E. Y., Vasseur, C. M., & Seebeck, F. P. (2024). Enzyme-catalyzed oxidative degradation of ergothioneine. Angewandte Chemie International Edition, 63(8), e202318445 (8 pp.). https://doi.org/10.1002/anie.202318445
Discovery and biochemical characterization of thermostable glycerol oxidases
Santema, L. L., Rotilio, L., Xiang, R., Tjallinks, G., Guallar, V., Mattevi, A., & Fraaije, M. W. (2024). Discovery and biochemical characterization of thermostable glycerol oxidases. Applied Microbiology and Biotechnology, 108, 61 (14 pp.). https://doi.org/10.1007/s00253-023-12883-9
 

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