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Bistable photoswitch allows in vivo control of hematopoiesis
Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., … Vázquez, O. (2022). Bistable photoswitch allows in vivo control of hematopoiesis. ACS Central Science, 8(1), 57-66. https://doi.org/10.1021/acscentsci.1c00434
Structural insights into the mechanism of archaellar rotational switching
Altegoer, F., Quax, T. E. F., Weiland, P., Nußbaum, P., Giammarinaro, P. I., Patro, M., … Bange, G. (2022). Structural insights into the mechanism of archaellar rotational switching. Nature Communications, 13(1), 2857 (12 pp.). https://doi.org/10.1038/s41467-022-30358-9
Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study
Anduix-Canto, C., Peral, D., Pérez-Padilla, V., Diaz-Rovira, A. M., Belmez Lledó, A., Orme, C. A., … Chou, K. W. (2022). Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study. Advanced Materials Interfaces, 9(1), 2101447 (10 pp.). https://doi.org/10.1002/admi.202101447
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
Astro, V., Ramirez-Calderon, G., Pennucci, R., Caroli, J., Saera-Vila, A., Cardona-Londoño, K., … Adamo, A. (2022). Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. iScience, 25(7), 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665
Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ
Auman, D., Ecker, F., Mader, S. L., Dorst, K. M., Bräuer, A., Widmalm, G., … Kaila, V. R. I. (2022). Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ. Journal of the American Chemical Society, 144(34), 15622-15632. https://doi.org/10.1021/jacs.2c05650
The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates
Aziz, I., Kaltwasser, S., Kayastha, K., Khera, R., Vonck, J., & Ermler, U. (2022). The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates. Journal of Inorganic Biochemistry, 234, 111904 (9 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111904
Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
Baudrexl, M., Fida, T., Berk, B., Schwarz, W. H., Zverlov, V. V., Groll, M., & Liebl, W. (2022). Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity. Frontiers in Molecular Biosciences, 9, 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439
An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity
Beaumet, M., Dose, A., Bräuer, A., Mahy, J. P., Ghattas, W., Groll, M., & Hess, C. R. (2022). An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity. Journal of Inorganic Biochemistry, 235, 111914 (5 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111914
Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Begnini, F., Geschwindner, S., Johansson, P., Wissler, L., Lewis, R. J., Danelius, E., … Kihlberg, J. (2022). Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction. Journal of Medicinal Chemistry, 65(4), 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
Slow magnetic relaxation of dy adatoms with in-plane magnetic anisotropy on a two-dimensional electron gas
Bellini, V., Rusponi, S., Kolorenč, J., Mahatha, S. K., Valbuena, M. A., Persichetti, L., … Barla, A. (2022). Slow magnetic relaxation of dy adatoms with in-plane magnetic anisotropy on a two-dimensional electron gas. ACS Nano, 16(7), 11182-11193. https://doi.org/10.1021/acsnano.2c04048
1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis
Bereiter, R., Renard, E., Breuker, K., Kreutz, C., Ennifar, E., & Micura, R. (2022). 1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis. Journal of the American Chemical Society, 144(23), 10344-10352. https://doi.org/10.1021/jacs.2c01877
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
Biebl, M. M., Delhommel, F., Faust, O., Zak, K. M., Agam, G., Guo, X., … Buchner, J. (2022). NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular Cell, 82(3), 555-569.e7. https://doi.org/10.1016/j.molcel.2021.12.031
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B<sub>12</sub> uptake route
Bloch, J. S., Sequeira, J. M., Ramírez, A. S., Quadros, E. V., & Locher, K. P. (2022). Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route. FASEB Journal, 36(4), e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
Exploring aspartic protease inhibitor binding to design selective antimalarials
Bobrovs, R., Basens, E. E., Drunka, L., Kanepe, I., Matisone, S., Velins, K. K., … Jaudzems, K. (2022). Exploring aspartic protease inhibitor binding to design selective antimalarials. Journal of Chemical Information and Modeling, 62(13), 3263-3273. https://doi.org/10.1021/acs.jcim.2c00422
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., … Helleday, T. (2022). Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer, 3(2), 156-172. https://doi.org/10.1038/s43018-022-00331-y
Structural organization of the spongy mesophyll
Borsuk, A. M., Roddy, A. B., Théroux‐Rancourt, G., & Brodersen, C. R. (2022). Structural organization of the spongy mesophyll. New Phytologist, 234(3), 946-960. https://doi.org/10.1111/nph.17971
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
Bärland, N., Rueff, A. S., Cebrero, G., Hutter, C. A. J., Seeger, M. A., Veening, J. W., & Perez, C. (2022). Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification. Science Advances, 8(9), eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
The role of root hairs in water uptake: recent advances and future perspectives
Cai, G., & Ahmed, M. A. (2022). The role of root hairs in water uptake: recent advances and future perspectives. Journal of Experimental Botany, 73(11), 3330-3338. https://doi.org/10.1093/jxb/erac114
Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes
Cansfield, A. D., Ator, M. A., Banerjee, J., Bestwick, M., Bortolato, A., Brown, G. A., … Watson, S. P. (2022). Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes. ACS Chemical Neuroscience, 13(6), 751-765. https://doi.org/10.1021/acschemneuro.1c00696
A litmus test for classifying recognition mechanisms of transiently binding proteins
Chakrabarti, K. S., Olsson, S., Pratihar, S., Giller, K., Overkamp, K., Lee, K. O., … Griesinger, C. (2022). A litmus test for classifying recognition mechanisms of transiently binding proteins. Nature Communications, 13(1), 3792 (11 pp.). https://doi.org/10.1038/s41467-022-31374-5
 

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