| A Novel inhibitor against the Bromodomain protein 1 of the malaria pathogen <em>Plasmodium Falciparum</em>
Amann, M., Warstat, R., Rechten, K. K., Theuer, P., Schustereder, M., Clavey, S., … Günther, S. (2025). A Novel inhibitor against the Bromodomain protein 1 of the malaria pathogen Plasmodium Falciparum. ChemMedChem, 20(11), e202500024 (5 pp.). https://doi.org/10.1002/cmdc.202500024 |
| The C-terminal PHD<sub>V</sub>C5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma
Berardi, A., Kaestner, C. L., Ghitti, M., Quilici, G., Cocomazzi, P., Li, J., … Musco, G. (2025). The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma. Nucleic Acids Research, 53(1), gkae1121 (20 pp.). https://doi.org/10.1093/nar/gkae1121 |
| Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
Bobadilla Ugarte, P., Halter, S., Mutte, S. K., Heijstek, C., Niault, T., Terenin, I., … Swarts, D. C. (2025). Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA. Molecular Cell, 85(10), 1920-1937.e10. https://doi.org/10.1016/j.molcel.2025.03.025 |
| Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron crystallography
Bosman, R., Ortolani, G., Ghosh, S., James, D., Norder, P., Hammarin, G., … Neutze, R. (2025). Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron crystallography. Nature Communications, 16(1), 3460 (12 pp.). https://doi.org/10.1038/s41467-025-58263-x |
| Discovery of CHF-6523, an inhaled selective PI3Kδ inhibitor for the treatment of chronic obstructive pulmonary disease
Bruno, P., Pala, D., Micoli, A., Corsi, M., Accetta, A., Carzaniga, L., … Capelli, A. M. (2025). Discovery of CHF-6523, an inhaled selective PI3Kδ inhibitor for the treatment of chronic obstructive pulmonary disease. Journal of Medicinal Chemistry, 68, 2444-2465. https://doi.org/10.1021/acs.jmedchem.4c02062 |
| The carbonyl nucleobase adduct M<sub>3</sub>Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
Chancellor, A., Constantin, D., Berloffa, G., Yang, Q., Nosi, V., Loureiro, J. P., … De Libero, G. (2025). The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells. Immunity, 58(2), 431-447. https://doi.org/10.1016/j.immuni.2024.11.019 |
| Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1
De Marco, M., Rai, S. R., Scietti, L., Mattoteia, D., Liberi, S., Moroni, E., … Forneris, F. (2025). Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1. Nature Communications, 16(1), 3624 (17 pp.). https://doi.org/10.1038/s41467-025-59017-5 |
| Biochemical and structural insights into pinoresinol hydroxylase from <em>Pseudomonas </em>sp
Guerriere, T. B., Fraaije, M. W., & Mattevi, A. (2025). Biochemical and structural insights into pinoresinol hydroxylase from Pseudomonas sp. Archives of Biochemistry and Biophysics, 764, 110247 (8 pp.). https://doi.org/10.1016/j.abb.2024.110247 |
| Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment
Guerriere, T. B., Vancheri, A., Ricotti, I., Serapian, S. A., Eggerichs, D., Tischler, D., … Mattevi, A. (2025). Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment. ACS Catalysis, 15(2), 1046-1060. https://doi.org/10.1021/acscatal.4c05944 |
| A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode
Hermanns, T., Kolek, S., Uthoff, M., de Heiden, R. A., Mulder, M. P. C., Baumann, U., & Hofmann, K. (2025). A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode. Molecular Cell, 85(6), 1202-1215.e5. https://doi.org/10.1016/j.molcel.2025.02.002 |
| Trivalent siRNA-conjugates with guanosine as ASGPR-binder show potent knock-down in vivo
Hofmeister, A., Jahn-Hofmann, K., Brunner, B., Helms, M., Metz-Weidmann, C., Poeverlein, C., … Scheidler, S. (2025). Trivalent siRNA-conjugates with guanosine as ASGPR-binder show potent knock-down in vivo. Journal of Medicinal Chemistry, 68(6), 6193-6209. https://doi.org/10.1021/acs.jmedchem.4c02275 |
| Molecular basis for azetidine-2-carboxylic acid biosynthesis
Klaubert, T. J., Gellner, J., Bernard, C., Effert, J., Lombard, C., Kaila, V. R. I., … Groll, M. (2025). Molecular basis for azetidine-2-carboxylic acid biosynthesis. Nature Communications, 16(1), 48 (12 pp.). https://doi.org/10.1038/s41467-025-56610-6 |
| S<sub>N</sub>Ar reactive pyrazine derivatives as p53-Y220C cleft binders with diverse binding modes
Klett, T., Stahlecker, J., Schwer, M., Jaag, S. J., Masberg, B., Knappe, C., … Boeckler, F. M. (2025). SNAr reactive pyrazine derivatives as p53-Y220C cleft binders with diverse binding modes. Drug Design, Development and Therapy, 19, 4727-4753. https://doi.org/10.2147/DDDT.S513792 |
| Mechanism of read-through enhancement by aminoglycosides and mefloquine
Kolosova, O., Zgadzay, Y., Stetsenko, A., Sukhinina, A. P., Atamas, A., Validov, S., … Yusupov, M. (2025). Mechanism of read-through enhancement by aminoglycosides and mefloquine. Proceedings of the National Academy of Sciences of the United States of America PNAS, 122(17) (12 pp.). https://doi.org/10.1073/pnas.2420261122 |
| Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Lotz, R., Osterburg, C., Chaikuad, A., Weber, S., Akutsu, M., Machel, A. C., … Dötsch, V. (2025). Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro. Cell Death and Disease, 16(1), 4 (11 pp.). https://doi.org/10.1038/s41419-024-07320-2 |
| Unravelling the amyloid aggregation mechanism of the sweet protein Monellin: Insights from circular permutated mutants
Lucignano, R., Bologna, A., Gramazio, S., Wang, P. H., Taxis, C., Essen, L. O., … Spadaccini, R. (2025). Unravelling the amyloid aggregation mechanism of the sweet protein Monellin: Insights from circular permutated mutants. International Journal of Biological Macromolecules, 308, 142239 (11 pp.). https://doi.org/10.1016/j.ijbiomac.2025.142239 |
| Thieno[3,2<em>-b</em>]pyridine: attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
Moyano, P. M., Kubina, T., Paruch, Š. O., Jarošková, A., Novotný, J., Skočková, V., … Paruch, K. (2025). Thieno[3,2-b]pyridine: attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Angewandte Chemie International Edition, 64(1), e202412786 (11 pp.). https://doi.org/10.1002/anie.202412786 |
| Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers
Mühle, J., Alenfelder, J., Rodrigues, M. J., Jürgenliemke, L., Guixà-González, R., Grätz, L., … Deupi, X. (2025). Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers. Proceedings of the National Academy of Sciences of the United States of America PNAS, 122(19), e2418398122 (12 pp.). https://doi.org/10.1073/pnas.2418398122 |
| DARPin-induced reactivation of p53 in HPV-positive cells
Münick, P., Strubel, A., Balourdas, D. I., Funk, J. S., Mernberger, M., Osterburg, C., … Dötsch, V. (2025). DARPin-induced reactivation of p53 in HPV-positive cells. Nature Structural and Molecular Biology, 1842 (823 pp.). https://doi.org/10.1038/s41594-024-01456-7 |
| STX-721, a covalent EGFR/HER2 Exon 20 inhibitor, utilizes exon 20–mutant dynamic protein states and achieves unique mutant selectivity across human cancer models
Pagliarini, R. A., Henderson, J. A., Milgram, B. C., Borrelli, D. R., Brooijmans, N., Hilbert, B. J., … Stuart, D. D. (2025). STX-721, a covalent EGFR/HER2 Exon 20 inhibitor, utilizes exon 20–mutant dynamic protein states and achieves unique mutant selectivity across human cancer models. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-24-3833 |
