| Development of a series of pyrrolopyridone MAT2A inhibitors
Atkinson, S. J., Bagal, S. K., Argyrou, A., Askin, S., Cheung, T., Chiarparin, E., … Williamson, B. (2024). Development of a series of pyrrolopyridone MAT2A inhibitors. Journal of Medicinal Chemistry, 67(6), 4541-4559. https://doi.org/10.1021/acs.jmedchem.3c01860 |
| Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., De Falco, L., Dyson, P. J., & Davey, C. A. (2024). Viral peptide conjugates for metal-warhead delivery to chromatin. RSC Advances, 14(13), 8718-8725. https://doi.org/10.1039/d4ra01617c |
| Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
Bauer, N., Balourdas, D. I., Schneider, J. R., Zhang, X., Berger, L. M., Berger, B. T., … Joerger, A. C. (2024). Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization. ACS Chemical Biology, 19(2), 266-279. https://doi.org/10.1021/acschembio.3c00427 |
| Peptide-based covalent inhibitors bearing mild electrophiles to target a conserved his residue of the bacterial sliding clamp
Compain, G., Monsarrat, C., Blagojevic, J., Brillet, K., Dumas, P., Hammann, P., … Guichard, G. (2024). Peptide-based covalent inhibitors bearing mild electrophiles to target a conserved his residue of the bacterial sliding clamp. JACS Au, 4(2), 432-440. https://doi.org/10.1021/jacsau.3c00572 |
| The catalytic mechanism of the RNA methyltransferase METTL3
Corbeski, I., Vargas-Rosales, P. A., Bedi, R. K., Deng, J., Coelho, D., Braud, E., … Caflisch, A. (2024). The catalytic mechanism of the RNA methyltransferase METTL3. eLife, 12, RP92537 (27 pp.). https://doi.org/10.7554/eLife.92537 |
| Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism
D'Agostino, M., Simonetti, A., Motta, S., Wolff, P., Romagnoli, A., Piccinini, A., … Ennifar, E. (2024). Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism. Structure, 32(7), 878-888.e4. https://doi.org/10.1016/j.str.2024.03.008 |
| Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Fu, C., Liu, Y., Walt, C., Rasheed, S., Bader, C. D., Lukat, P., … Müller, R. (2024). Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature Communications, 15(1), 791 (13 pp.). https://doi.org/10.1038/s41467-024-44953-5 |
| Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
Greco, F. A., Krämer, A., Wahl, L., Elson, L., Ehret, T. A. L., Gerninghaus, J., … Knapp, S. (2024). Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting. European Journal of Medicinal Chemistry, 276, 116672 (22 pp.). https://doi.org/10.1016/j.ejmech.2024.116672 |
| Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches
Hazemann, J., Kimmerlin, T., Lange, R., Sweeney, A. M., Bourquin, G., Ritz, D., & Czodrowski, P. (2024). Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches. RSC Medicinal Chemistry, 15(6), 2146-2159. https://doi.org/10.1039/d4md00106k |
| Structure–function relationships underpin disulfide loop cleavage-dependent activation of <em>Legionella pneumophila</em> lysophospholipase A PlaA
Hiller, M., Diwo, M., Wamp, S., Gutsmann, T., Lang, C., Blankenfeldt, W., & Flieger, A. (2024). Structure–function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular Microbiology, 121(3), 497-512. https://doi.org/10.1111/mmi.15201 |
| Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1), 462-473. https://doi.org/10.1093/nar/gkad1102 |
| Molecular engineering of insulin for recombinant expression in yeast
Kjeldsen, T., Andersen, A. S., Hubálek, F., Johansson, E., Kreiner, F. F., Schluckebier, G., & Kurtzhals, P. (2024). Molecular engineering of insulin for recombinant expression in yeast. Trends in Biotechnology, 42(4), 464-478. https://doi.org/10.1016/j.tibtech.2023.09.012 |
| Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine <em>Methanococcales</em>
Maslać, N., Cadoux, C., Bolte, P., Murken, F., Gu, W., Milton, R. D., & Wagner, T. (2024). Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales. FEBS Journal, 291(15), 3454-3480. https://doi.org/10.1111/febs.17148 |
| Real time and highly sensitive sub-wavelength 2D hybrid perovskite photodetectors
Mastria, R., Riisnaes, K. J., Bacon, A., Leontis, I., Lam, H. T., Alshehri, M. A. S., … Russo, S. (2024). Real time and highly sensitive sub-wavelength 2D hybrid perovskite photodetectors. Advanced Functional Materials. https://doi.org/10.1002/adfm.202401903 |
| Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex
Meinhold, S., Zdanowicz, R., Giese, C., & Glockshuber, R. (2024). Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex. Science Advances, 10(6), eadj6358 (17 pp.). https://doi.org/10.1126/sciadv.adj6358 |
| Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design
Mukherjee, M., Day, P. J., Laverty, D., Bueren-Calabuig, J. A., Woodhead, A. J., Griffiths-Jones, C., … O'Reilly, M. (2024). Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 32(8), 1040-1048.e3. https://doi.org/10.1016/j.str.2024.05.011 |
| Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations
Müller, M. C., Lemaire, O. N., Kurth, J. M., Welte, C. U., & Wagner, T. (2024). Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Communications Biology, 7(1), 111. https://doi.org/10.1038/s42003-023-05726-w |
| A ligand discovery toolbox for the WWE domain family of human E3 ligases
Münzker, L., Kimani, S. W., Fowkes, M. M., Dong, A., Zheng, H., Li, Y., … Böttcher, J. (2024). A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications Biology, 7(1), 901 (15 pp.). https://doi.org/10.1038/s42003-024-06584-w |
| Enzyme-catalyzed oxidative degradation of ergothioneine
Nalivaiko, E. Y., Vasseur, C. M., & Seebeck, F. P. (2024). Enzyme-catalyzed oxidative degradation of ergothioneine. Angewandte Chemie International Edition, 63(8), e202318445 (8 pp.). https://doi.org/10.1002/anie.202318445 |
| Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Ober, V. T., Githure, G. B., Volpato Santos, Y., Becker, S., Moya Munoz, G., Basquin, J., … Boshart, M. (2024). Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. eLife, 12, RP91040 (33 pp.). https://doi.org/10.7554/eLife.91040 |
