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Peptide-based covalent inhibitors bearing mild electrophiles to target a conserved his residue of the bacterial sliding clamp
Compain, G., Monsarrat, C., Blagojevic, J., Brillet, K., Dumas, P., Hammann, P., … Guichard, G. (2024). Peptide-based covalent inhibitors bearing mild electrophiles to target a conserved his residue of the bacterial sliding clamp. JACS Au, 4(2), 432-440. https://doi.org/10.1021/jacsau.3c00572
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Fu, C., Liu, Y., Walt, C., Rasheed, S., Bader, C. D., Lukat, P., … Müller, R. (2024). Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature Communications, 15(1), 791 (13 pp.). https://doi.org/10.1038/s41467-024-44953-5
Structure–function relationships underpin disulfide loop cleavage-dependent activation of <em>Legionella pneumophila</em> lysophospholipase A PlaA
Hiller, M., Diwo, M., Wamp, S., Gutsmann, T., Lang, C., Blankenfeldt, W., & Flieger, A. (2024). Structure–function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular Microbiology, 121(3), 497-512. https://doi.org/10.1111/mmi.15201
Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1), 462-473. https://doi.org/10.1093/nar/gkad1102
Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex
Meinhold, S., Zdanowicz, R., Giese, C., & Glockshuber, R. (2024). Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex. Science Advances, 10(6), eadj6358 (17 pp.). https://doi.org/10.1126/sciadv.adj6358
Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations
Müller, M. C., Lemaire, O. N., Kurth, J. M., Welte, C. U., & Wagner, T. (2024). Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Communications Biology, 7(1), 111. https://doi.org/10.1038/s42003-023-05726-w
Enzyme-catalyzed oxidative degradation of ergothioneine
Nalivaiko, E. Y., Vasseur, C. M., & Seebeck, F. P. (2024). Enzyme-catalyzed oxidative degradation of ergothioneine. Angewandte Chemie International Edition, 63(8), e202318445 (8 pp.). https://doi.org/10.1002/anie.202318445
Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., … Koehnke, J. (2023). Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), 560-568. https://doi.org/10.1038/s41557-023-01153-w
Turning universal O into rare Bombay type blood
Anso, I., Naegeli, A., Cifuente, J. O., Orrantia, A., Andersson, E., Zenarruzabeitia, O., … Guerin, M. E. (2023). Turning universal O into rare Bombay type blood. Nature Communications, 14(1), 1765 (16 pp.). https://doi.org/10.1038/s41467-023-37324-z
Targeting the alternative vitamin E metabolite binding site enables noncanonical PPAR<em>γ</em> modulation
Arifi, S., Marschner, J. A., Pollinger, J., Isigkeit, L., Heitel, P., Kaiser, A., … Merk, D. (2023). Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation. Journal of the American Chemical Society, 145(27), 14802-14810. https://doi.org/10.1021/jacs.3c03417
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Bashore, F. M., Marquez, A. B., Chaikuad, A., Howell, S., Dunn, A. S., Beltran, A. A., … Axtman, A. D. (2023). Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific Reports, 13(1), 6118 (17 pp.). https://doi.org/10.1038/s41598-023-32854-4
Structure-based design of inhibitors of the m<sup>6</sup>A-RNA writer enzyme METTL3
Bedi, R. K., Huang, D., Li, Y., & Caflisch, A. (2023). Structure-based design of inhibitors of the m6A-RNA writer enzyme METTL3. ACS Bio & Med Chem Au, 3(4), 359-370. https://doi.org/10.1021/acsbiomedchemau.3c00023
Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
Billiald, P., Slater, A., Welin, M., Clark, J. C., Loyau, S., Pugnière, M., … Jandrot-Perrus, M. (2023). Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances, 7(7), 1258-1268. https://doi.org/10.1182/bloodadvances.2022007863
Maytansinol functionalization: towards useful probes for studying microtubule dynamics
Boiarska, Z., Pérez-Peña, H., Abel, A. C., Marzullo, P., Álvarez-Bernad, B., Bonato, F., … Passarella, D. (2023). Maytansinol functionalization: towards useful probes for studying microtubule dynamics. Chemistry: A European Journal, 29(5), e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., … Gruic-Sovulj, I. (2023). Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nature Communications, 14(1), 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3
Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry
Bui, T. Y. H., De Zitter, E., Moeyaert, B., Pecqueur, L., Srinivasu, B. Y., Economou, A., … Pedre, B. (2023). Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry. International Journal of Biological Macromolecules, 239, 124179 (9 pp.). https://doi.org/10.1016/j.ijbiomac.2023.124179
Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from <em>Escherichia coli</em>
Busch, M. R., Rajendran, C., & Sterner, R. (2023). Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli. Biochemistry, 62(3), 863-872. https://doi.org/10.1021/acs.biochem.2c00640
Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase
Cadoux, C., Ratcliff, D., Maslać, N., Gu, W., Tsakoumagkos, I., Hoogendoorn, S., … Milton, R. D. (2023). Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase. JACS Au, 3(5), 1521-1533. https://doi.org/10.1021/jacsau.3c00165
The mononuclear metal-binding site of Mo-nitrogenase is not required for activity
Cadoux, C., Maslać, N., Di Luzio, L., Ratcliff, D., Gu, W., Wagner, T., & Milton, R. D. (2023). The mononuclear metal-binding site of Mo-nitrogenase is not required for activity. JACS Au, 3(11), 2993-2999. https://doi.org/10.1021/jacsau.3c00567
Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome
Chandra, M., Đaković, S., Foti, K., Zeelen, J. P., van Straaten, M., Aresta-Branco, F., … Stebbins, C. E. (2023). Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome. PLoS Neglected Tropical Diseases, 17(2), e0011093 (18 pp.). https://doi.org/10.1371/journal.pntd.0011093
 

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