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Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778
Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source
Leonarski, F., Nan, J., Matej, Z., Bertrand, Q., Furrer, A., Gorgisyan, I., … Dworkowski, F. (2023). Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source. IUCrJ, 10(6), 729-737. https://doi.org/10.1107/S2052252523008618
Expanding the application range of microbial oxidoreductases by an alcohol dehydrogenase from <em>Comamonas testosteroni</em> with a broad substrate spectrum and pH profile
Bakonyi, D., Toelzer, C., Stricker, M., Hummel, W., Niefind, K., & Gröger, H. (2020). Expanding the application range of microbial oxidoreductases by an alcohol dehydrogenase from Comamonas testosteroni with a broad substrate spectrum and pH profile. Catalysts, 10(11), 1281 (14 pp.). https://doi.org/10.3390/catal10111281
The molecular basis of the interaction of cyclophilin A with α-synuclein
Favretto, F., Baker, J. D., Strohäker, T., Andreas, L. B., Blair, L. J., Becker, S., & Zweckstetter, M. (2020). The molecular basis of the interaction of cyclophilin A with α-synuclein. Angewandte Chemie International Edition, 59(14), 5692-5695. https://doi.org/10.1002/anie.201914878
Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism
Brünle, S., Eisinger, M. L., Poppe, J., Mills, D. J., Langer, J. D., Vonck, J., & Ermler, U. (2019). Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America PNAS, 116(52), 26497-26504. https://doi.org/10.1073/pnas.1913031116
Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., … Grossmann, T. N. (2019). Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly. Angewandte Chemie International Edition, 58(48), 17351-17358. https://doi.org/10.1002/anie.201907901
Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach
Kaur, H., Hartmann, J. B., Jakob, R. P., Zahn, M., Zimmermann, I., Maier, T., … Hiller, S. (2019). Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. Journal of Biomolecular NMR, 73(6-7), 375-384. https://doi.org/10.1007/s10858-019-00250-8
The bacterial [Fe]-hydrogenase paralog HmdII uses tetrahydrofolate derivatives as substrates
Watanabe, T., Wagner, T., Huang, G., Kahnt, J., Ataka, K., Ermler, U., & Shima, S. (2019). The bacterial [Fe]-hydrogenase paralog HmdII uses tetrahydrofolate derivatives as substrates. Angewandte Chemie International Edition, 58(11), 3506-3510. https://doi.org/10.1002/anie.201813465
A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography
de Wijn, R., Hennig, O., Roche, J., Engilberge, S., Rollet, K., Fernandez-Millan, P., … Sauter, C. (2019). A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography. IUCrJ, 6(3), 454-464. https://doi.org/10.1107/S2052252519003622
An interface-driven design strategy yields a novel, corrugated protein architecture
ElGamacy, M., Coles, M., Ernst, P., Zhu, H., Hartmann, M. D., Plückthun, A., & Lupas, A. N. (2018). An interface-driven design strategy yields a novel, corrugated protein architecture. ACS Synthetic Biology, 7(9), 2226-2235. https://doi.org/10.1021/acssynbio.8b00224
A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme
Dharadhar, S., Clerici, M., van Dijk, W. J., Fish, A., & Sixma, T. K. (2016). A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. Journal of Structural Biology, 196(3), 437-447. https://doi.org/10.1016/j.jsb.2016.09.011
Structural, biochemical, and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogues
Koch, M. F., Harteis, S., Blank, I. D., Pestel, G., Tietze, L. F., Ochsenfeld, C., … Sieber, S. A. (2015). Structural, biochemical, and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogues. Angewandte Chemie International Edition, 54(46), 13550-13554. https://doi.org/10.1002/anie.201505749
A druggable pocket at the nucleocapsid/phosphoprotein interaction site of human respiratory syncytial virus
Ouizougun-Oubari, M., Pereira, N., Tarus, B., Galloux, M., Lassoued, S., Fix, J., … Duquerroy, S. (2015). A druggable pocket at the nucleocapsid/phosphoprotein interaction site of human respiratory syncytial virus. Journal of Virology, 89(21), 11129-11143. https://doi.org/10.1128/JVI.01612-15
Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure
Reichen, C., Madhurantakam, C., Plückthun, A., & Mittl, P. R. E. (2014). Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure. Protein Science, 23(11), 1572-1583. https://doi.org/10.1002/pro.2535
A stomatin dimer modulates the activity of acid-sensing ion channels
Brand, J., Smith, E. S. J., Schwefel, D., Lapatsina, L., Poole, K., Omerbašić, D., … Daumke, O. (2012). A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO Journal, 31(17), 3635-3646. https://doi.org/10.1038/emboj.2012.203
Structure-based optimization of designed armadillo-repeat proteins
Madhurantakam, C., Varadamsetty, G., Grütter, M. G., Plückthun, A., & Mittl, P. R. E. (2012). Structure-based optimization of designed armadillo-repeat proteins. Protein Science, 21(7), 1015-1028. https://doi.org/10.1002/pro.2085
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Schmid, A. B., Lagleder, S., Gräwert, M. A., Röhl, A., Hagn, F., Wandinger, S. K., … Buchner, J. (2012). The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO Journal, 31(6), 1506-1517. https://doi.org/10.1038/emboj.2011.472
Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity
Schuller, J. M., Zocher, G., Liebhold, M., Xie, X., Stahl, M., Li, S. M., & Stehle, T. (2012). Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity. Journal of Molecular Biology, 422(1), 87-99. https://doi.org/10.1016/j.jmb.2012.05.033
Biochemical and structural characterization of <em>Plasmodium falciparum</em> glutamate dehydrogenase 2
Zocher, K., Fritz-Wolf, K., Kehr, S., Fischer, M., Rahlfs, S., & Becker, K. (2012). Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2. Molecular and Biochemical Parasitology, 183(1), 52-62. https://doi.org/10.1016/j.molbiopara.2012.01.007
Target highlights in CASP9: experimental target structures for the critical assessment of techniques for protein structure prediction
Kryshtafovych, A., Moult, J., Bartual, S. G., Bazan, J. F., Berman, H., Casteel, D. E., … Schwede, T. (2011). Target highlights in CASP9: experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins, 79(Suppl. 10), 6-20. https://doi.org/10.1002/prot.23196