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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Napolitano, V., Dabrowska, A., Schorpp, K., Mourão, A., Barreto-Duran, E., Benedyk, M., … Pyrc, K. (2022). Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chemical Biology, 29(5), 774-784.e8. https://doi.org/10.1016/j.chembiol.2021.11.006
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., … Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chemical Biology, 28(5), 686-698. https://doi.org/10.1016/j.chembiol.2021.01.003
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
Larraufie, M. H., Gao, X., Xia, X., Devine, P. J., Kallen, J., Liu, D., … Wang, S. (2021). Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chemical Biology, 28(9), 1271-1282. https://doi.org/10.1016/j.chembiol.2021.04.001
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
Scott, D. E., Francis-Newton, N. J., Marsh, M. E., Coyne, A. G., Fischer, G., Moschetti, T., … Abell, C. (2021). A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology, 28(6), 835-847.e5. https://doi.org/10.1016/j.chembiol.2021.02.006
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Wells, C. I., Drewry, D. H., Pickett, J. E., Tjaden, A., Krämer, A., Müller, S., … Axtman, A. D. (2021). Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chemical Biology, 28(4), 546-558. https://doi.org/10.1016/j.chembiol.2020.12.013
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions
Willems, S., Gellrich, L., Chaikuad, A., Kluge, S., Werz, O., Heering, J., … Merk, D. (2021). Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. Cell Chemical Biology, 28(10), 1489-1500.e8. https://doi.org/10.1016/j.chembiol.2021.04.019
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, S. M., Rehling, D., Jemth, A. S., Throup, A., Landázuri, N., Almlöf, I., … Helleday, T. (2021). NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chemical Biology, 28(12), 1693-1702. https://doi.org/10.1016/j.chembiol.2021.06.001
Targeted <em>in situ</em> protein diversification and intra-organelle validation in mammalian cells
Erdogan, M., Fabritius, A., Basquin, J., & Griesbeck, O. (2020). Targeted in situ protein diversification and intra-organelle validation in mammalian cells. Cell Chemical Biology, 27(5), 610-621. https://doi.org/10.1016/j.chembiol.2020.02.004
Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms
Maculins, T., Garcia-Pardo, J., Skenderovic, A., Gebel, J., Putyrski, M., Vorobyov, A., … Dikic, I. (2020). Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms. Cell Chemical Biology, 27(11), 1441-1451.e7. https://doi.org/10.1016/j.chembiol.2020.07.010
Light regulation of enzyme allostery through photo-responsive unnatural amino acids
Kneuttinger, A. C., Straub, K., Bittner, P., Simeth, N. A., Bruckmann, A., Busch, F., … Sterner, R. (2019). Light regulation of enzyme allostery through photo-responsive unnatural amino acids. Cell Chemical Biology, 26(11), 1501-1514.e9. https://doi.org/10.1016/j.chembiol.2019.08.006
Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol
Li, M., Müller, C., Fröhlich, K., Gorka, O., Zhang, L., Groß, O., … Jessen-Trefzer, C. (2019). Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol. Cell Chemical Biology, 26(6), 852-862.e6. https://doi.org/10.1016/j.chembiol.2019.03.002
Leveraging compound promiscuity to identify targetable cysteines within the kinome
Rao, S., Gurbani, D., Du, G., Everley, R. A., Browne, C. M., Chaikuad, A., … Gray, N. S. (2019). Leveraging compound promiscuity to identify targetable cysteines within the kinome. Cell Chemical Biology, 26(6), 818-829.e9. https://doi.org/10.1016/j.chembiol.2019.02.021
Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties
Pries, V., Nöcker, C., Khan, D., Johnen, P., Hong, Z., Tripathi, A., … Hoepfner, D. (2018). Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chemical Biology, 25(3), 279-290. https://doi.org/10.1016/j.chembiol.2017.12.007
Inhibition of eukaryotic translation by the antitumor natural product agelastatin A
McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., … Liu, J. O. (2017). Inhibition of eukaryotic translation by the antitumor natural product agelastatin A. Cell Chemical Biology, 24(5), 605-613.e5. https://doi.org/10.1016/j.chembiol.2017.04.006
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin
Storm, P. A., Herbst, D. A., Maier, T., & Townsend, C. A. (2017). Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chemical Biology, 24(3), 316-325. https://doi.org/10.1016/j.chembiol.2017.01.008
Triazolopyrimidines are microtubule-stabilizing agents that bind the vinca inhibitor site of tubulin
Sáez-Calvo, G., Sharma, A., de Asís Balaguer, F., Barasoain, I., Rodríguez-Salarichs, J., Olieric, N., … Díaz, J. F. (2017). Triazolopyrimidines are microtubule-stabilizing agents that bind the vinca inhibitor site of tubulin. Cell Chemical Biology, 24(6), 737-750. https://doi.org/10.1016/j.chembiol.2017.05.016
Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes
Busch, F., Rajendran, C., Heyn, K., Schlee, S., Merkl, R., & Sterner, R. (2016). Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes. Cell Chemical Biology, 23(6), 709-715. https://doi.org/10.1016/j.chembiol.2016.05.009
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase
Schulze, J. O., Saladino, G., Busschots, K., Neimanis, S., Süß, E., Odadzic, D., … Biondi, R. M. (2016). Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chemical Biology, 23(10), 1193-1205. https://doi.org/10.1016/j.chembiol.2016.06.017
Epiblastin A Induces Reprogramming of Epiblast Stem Cells into Embryonic Stem Cells by Inhibition of Casein Kinase 1
Ursu, A., Illich, D. J., Takemoto, Y., Porfetye, A. T., Zhang, M., Brockmeyer, A., … Waldmann, H. (2016). Epiblastin A Induces Reprogramming of Epiblast Stem Cells into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chemical Biology, 23(4), 494-507. https://doi.org/10.1016/j.chembiol.2016.02.015