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Autotaxin facilitates selective LPA receptor signaling
Salgado-Polo, F., Borza, R., Matsoukas, M. T., Marsais, F., Jagerschmidt, C., Waeckel, L., … Perrakis, A. (2023). Autotaxin facilitates selective LPA receptor signaling. Cell Chemical Biology, 30(1), 69-84.e14. https://doi.org/10.1016/j.chembiol.2022.12.006
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
Schwalm, M. P., Krämer, A., Dölle, A., Weckesser, J., Yu, X., Jin, J., … Knapp, S. (2023). Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chemical Biology, 30(7), 753-765.e8. https://doi.org/10.1016/j.chembiol.2023.06.002
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Napolitano, V., Dabrowska, A., Schorpp, K., Mourão, A., Barreto-Duran, E., Benedyk, M., … Pyrc, K. (2022). Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chemical Biology, 29(5), 774-784.e8. https://doi.org/10.1016/j.chembiol.2021.11.006
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., … Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chemical Biology, 28(5), 686-698. https://doi.org/10.1016/j.chembiol.2021.01.003
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
Larraufie, M. H., Gao, X., Xia, X., Devine, P. J., Kallen, J., Liu, D., … Wang, S. (2021). Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chemical Biology, 28(9), 1271-1282. https://doi.org/10.1016/j.chembiol.2021.04.001
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
Scott, D. E., Francis-Newton, N. J., Marsh, M. E., Coyne, A. G., Fischer, G., Moschetti, T., … Abell, C. (2021). A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology, 28(6), 835-847.e5. https://doi.org/10.1016/j.chembiol.2021.02.006
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Wells, C. I., Drewry, D. H., Pickett, J. E., Tjaden, A., Krämer, A., Müller, S., … Axtman, A. D. (2021). Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chemical Biology, 28(4), 546-558. https://doi.org/10.1016/j.chembiol.2020.12.013
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions
Willems, S., Gellrich, L., Chaikuad, A., Kluge, S., Werz, O., Heering, J., … Merk, D. (2021). Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. Cell Chemical Biology, 28(10), 1489-1500.e8. https://doi.org/10.1016/j.chembiol.2021.04.019
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, S. M., Rehling, D., Jemth, A. S., Throup, A., Landázuri, N., Almlöf, I., … Helleday, T. (2021). NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chemical Biology, 28(12), 1693-1702. https://doi.org/10.1016/j.chembiol.2021.06.001
Targeted <em>in situ</em> protein diversification and intra-organelle validation in mammalian cells
Erdogan, M., Fabritius, A., Basquin, J., & Griesbeck, O. (2020). Targeted in situ protein diversification and intra-organelle validation in mammalian cells. Cell Chemical Biology, 27(5), 610-621. https://doi.org/10.1016/j.chembiol.2020.02.004
Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms
Maculins, T., Garcia-Pardo, J., Skenderovic, A., Gebel, J., Putyrski, M., Vorobyov, A., … Dikic, I. (2020). Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms. Cell Chemical Biology, 27(11), 1441-1451.e7. https://doi.org/10.1016/j.chembiol.2020.07.010
Light regulation of enzyme allostery through photo-responsive unnatural amino acids
Kneuttinger, A. C., Straub, K., Bittner, P., Simeth, N. A., Bruckmann, A., Busch, F., … Sterner, R. (2019). Light regulation of enzyme allostery through photo-responsive unnatural amino acids. Cell Chemical Biology, 26(11), 1501-1514.e9. https://doi.org/10.1016/j.chembiol.2019.08.006
Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol
Li, M., Müller, C., Fröhlich, K., Gorka, O., Zhang, L., Groß, O., … Jessen-Trefzer, C. (2019). Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol. Cell Chemical Biology, 26(6), 852-862.e6. https://doi.org/10.1016/j.chembiol.2019.03.002
Leveraging compound promiscuity to identify targetable cysteines within the kinome
Rao, S., Gurbani, D., Du, G., Everley, R. A., Browne, C. M., Chaikuad, A., … Gray, N. S. (2019). Leveraging compound promiscuity to identify targetable cysteines within the kinome. Cell Chemical Biology, 26(6), 818-829.e9. https://doi.org/10.1016/j.chembiol.2019.02.021
Target identification and mechanism of action of picolinamide and benzamide chemotypes with antifungal properties
Pries, V., Nöcker, C., Khan, D., Johnen, P., Hong, Z., Tripathi, A., … Hoepfner, D. (2018). Target identification and mechanism of action of picolinamide and benzamide chemotypes with antifungal properties. Cell Chemical Biology, 25(3), 279-290.e7. https://doi.org/10.1016/j.chembiol.2017.12.007
Inhibition of eukaryotic translation by the antitumor natural product agelastatin A
McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., … Liu, J. O. (2017). Inhibition of eukaryotic translation by the antitumor natural product agelastatin A. Cell Chemical Biology, 24(5), 605-613.e5. https://doi.org/10.1016/j.chembiol.2017.04.006
Functional and structural analysis of programmed <em>C</em>-methylation in the biosynthesis of the fungal polyketide citrinin
Storm, P. A., Herbst, D. A., Maier, T., & Townsend, C. A. (2017). Functional and structural analysis of programmed C-methylation in the biosynthesis of the fungal polyketide citrinin. Cell Chemical Biology, 24(3), 316-325. https://doi.org/10.1016/j.chembiol.2017.01.008
Triazolopyrimidines are microtubule-stabilizing agents that bind the vinca inhibitor site of tubulin
Sáez-Calvo, G., Sharma, A., de Asís Balaguer, F., Barasoain, I., Rodríguez-Salarichs, J., Olieric, N., … Díaz, J. F. (2017). Triazolopyrimidines are microtubule-stabilizing agents that bind the vinca inhibitor site of tubulin. Cell Chemical Biology, 24(6), 737-750. https://doi.org/10.1016/j.chembiol.2017.05.016
Ancestral tryptophan synthase reveals functional sophistication of primordial enzyme complexes
Busch, F., Rajendran, C., Heyn, K., Schlee, S., Merkl, R., & Sterner, R. (2016). Ancestral tryptophan synthase reveals functional sophistication of primordial enzyme complexes. Cell Chemical Biology, 23(6), 709-715. https://doi.org/10.1016/j.chembiol.2016.05.009