| The catalytic mechanism of the RNA methyltransferase METTL3
Corbeski, I., Vargas-Rosales, P. A., Bedi, R. K., Deng, J., Coelho, D., Braud, E., … Caflisch, A. (2024). The catalytic mechanism of the RNA methyltransferase METTL3. eLife, 12, RP92537 (27 pp.). https://doi.org/10.7554/eLife.92537 |
| Ym1 protein crystals promote type 2 immunity
Heyndrickx, I., Deswarte, K., Verstraete, K., Verschueren, K. H. G., Smole, U., Aegerter, H., … Lambrecht, B. N. (2024). Ym1 protein crystals promote type 2 immunity. eLife, 12, RP90676 (17 pp.). https://doi.org/10.7554/eLife.90676 |
| Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Ober, V. T., Githure, G. B., Volpato Santos, Y., Becker, S., Moya Munoz, G., Basquin, J., … Boshart, M. (2024). Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. eLife, 12, RP91040 (33 pp.). https://doi.org/10.7554/eLife.91040 |
| PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association
Proske, M., Janowski, R., Bacher, S., Kang, H. S., Monecke, T., Koehler, T., … Niessing, D. (2024). PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. eLife, 13, RP93561 (27 pp.). https://doi.org/10.7554/eLife.93561 |
| Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
Goebel, L., Kirschner, T., Koska, S., Rai, A., Janning, P., Maffini, S., … Rauh, D. (2023). Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. eLife, 12, e82184 (22 pp.). https://doi.org/10.7554/elife.82184 |
| Structural insight into the stabilization of microtubules by taxanes
Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., … Díaz, J. F. (2023). Structural insight into the stabilization of microtubules by taxanes. eLife, 12, e84791 (35 pp.). https://doi.org/10.7554/elife.84791 |
| Structure of the connexin-43 gap junction channel in a putative closed state
Qi, C., Gutierrez, S. A., Lavriha, P., Othman, A., Lopez-Pigozzi, D., Bayraktar, E., … Korkhov, V. M. (2023). Structure of the connexin-43 gap junction channel in a putative closed state. eLife, 12, RP87616 (27 pp.). https://doi.org/10.7554/eLife.87616 |
| Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations
Sherratt, K., Gruson, H., Grah, R., Johnson, H., Niehus, R., Prasse, B., … Funk, S. (2023). Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations. eLife, 12, e81916 (19 pp.). https://doi.org/10.7554/eLife.81916 |
| How enzymatic activity is involved in chromatin organization
Das, R., Sakaue, T., Shivashankar, G. V., Prost, J., & Hiraiwa, T. (2022). How enzymatic activity is involved in chromatin organization. eLife, 11, e79901 (18 pp.). https://doi.org/10.7554/eLife.79901 |
| Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in <em>Xenopus </em>egg cytoplasmic extracts
Guyomar, C., Bousquet, C., Ku, S., Heumann, J. M., Guilloux, G., Gaillard, N., … Chrétien, D. (2022). Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts. eLife, 11, e83021 (26 pp.). https://doi.org/10.7554/eLife.83021 |
| GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., … Denzel, M. S. (2022). GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. eLife, 11, e69223 (29 pp.). https://doi.org/10.7554/eLife.69223 |
| Structural insights into recognition of chemokine receptors by <em>Staphylococcus</em> <em>aureus </em>leukotoxins
Lambey, P., Otun, O., Cong, X., Hoh, F., Brunel, L., Verdié, P., … Leyrat, C. (2022). Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. eLife, 11, e72555 (29 pp.). https://doi.org/10.7554/eLife.72555 |
| Structure of <em>Mycobacterium </em>tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
Mehta, V., Khanppnavar, B., Schuster, D., Kantarci, I., Vercellino, I., Kosturanova, A., … Korkhov, V. M. (2022). Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. eLife, 11, e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032 |
| Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
Muckenfuss, L. M., Migenda Herranz, A. C., Boneberg, F. M., Clerici, M., & Jinek, M. (2022). Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis. eLife, 11, e80332 (29 pp.). https://doi.org/10.7554/eLife.80332 |
| Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
Ramanadane, K., Straub, M. S., Dutzler, R., & Manatschal, C. (2022). Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. eLife, 11, e74589 (29 pp.). https://doi.org/10.7554/eLife.74589 |
| In situ X-ray-assisted electron microscopy staining for large biological samples
Ströh, S., Hammerschmith, E. W., Tank, D. W., Seung, H. S., & Wanner, A. A. (2022). In situ X-ray-assisted electron microscopy staining for large biological samples. eLife, 11, e72147 (19 pp.). https://doi.org/10.7554/eLife.72147 |
| Structure and ion-release mechanism of P<sub>IB-4</sub>-type ATPases
Grønberg, C., Hu, Q., Mahato, D. R., Longhin, E., Salustros, N., Duelli, A., … Gourdon, P. (2021). Structure and ion-release mechanism of PIB-4-type ATPases. eLife, 10, e73124 (21 pp.). https://doi.org/10.7554/eLife.73124 |
| Mcsb forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
Hajdusits, B., Suskiewicz, M. J., Hundt, N., Meinhart, A., Kurzbauer, R., Leodolter, J., … Clausen, T. (2021). Mcsb forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. eLife, 10, e63505 (24 pp.). https://doi.org/10.7554/eLife.63505 |
| Molecular architecture of the human tRNA ligase complex
Kroupova, A., Ackle, F., Asanović, I., Weitzer, S., Boneberg, F. M., Faini, M., … Jinek, M. (2021). Molecular architecture of the human tRNA ligase complex. eLife, 10, e71656 (28 pp.). https://doi.org/10.7554/eLife.71656 |
| The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel
Li, H., Huang, C. Y., Govorunova, E. G., Sineshchekov, O. A., Yi, A., Rothschild, K. J., … Spudich, J. L. (2021). The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel. eLife, 10, e65903 (14 pp.). https://doi.org/10.7554/eLife.65903 |
