Active Filters

  • (-) Keywords = drug discovery
Search Results 1 - 20 of 31
Select Page
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
Rübbelke, M., Fiegen, D., Bauer, M., Binder, F., Hamilton, J., King, J., … Zeeb, M. (2020). Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proceedings of the National Academy of Sciences of the United States of America PNAS, 117(52), 33272-33281. https://doi.org/10.1073/pnas.2017406117
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
Schubart, A., Anderson, K., Mainolfi, N., Sellner, H., Ehara, T., Adams, C. M., … Eder, J. (2019). Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America PNAS, 116(16), 7926-7931. https://doi.org/10.1073/pnas.1820892116
Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes
Andrei, S. A., Meijer, F. A., Neves, J. F., Brunsveld, L., Landrieu, I., Ottmann, C., & Milroy, L. G. (2018). Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes. ACS Chemical Neuroscience, 9(11), 2639-2654. https://doi.org/10.1021/acschemneuro.8b00118
Ligand channel in pharmacologically stabilized rhodopsin
Mattle, D., Kuhn, B., Aebi, J., Bedoucha, M., Kekilli, D., Grozinger, N., … Dawson, R. J. P. (2018). Ligand channel in pharmacologically stabilized rhodopsin. Proceedings of the National Academy of Sciences of the United States of America PNAS, 115(14), 3640-3645. https://doi.org/10.1073/pnas.1718084115
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease
Neumann, U., Ufer, M., Jacobson, L. H., Rouzade-Dominguez, M. L., Huledal, G., Kolly, C., … Lopez Lopez, C. (2018). The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO Molecular Medicine, 10(11), e9316 (18 pp.). https://doi.org/10.15252/emmm.201809316
Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors
Phoo, W. W., Zhang, Z., Wirawan, M., Chew, E. J. C., Chew, A. B. L., Kouretova, J., … Luo, D. (2018). Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Research, 160, 17-24. https://doi.org/10.1016/j.antiviral.2018.10.006
Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors
Heinzlmeir, S., Lohse, J., Treiber, T., Kudlinzki, D., Linhard, V., Gande, S. L., … Médard, G. (2017). Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12(12), 999-1011. https://doi.org/10.1002/cmdc.201700217
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles
Hügle, M., Lucas, X., Ostrovskyi, D., Regenass, P., Gerhardt, S., Einsle, O., … Wohlwend, D. (2017). Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angewandte Chemie International Edition, 56(41), 12476-12480. https://doi.org/10.1002/anie.201705516
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6
Kerres, N., Steurer, S., Schlager, S., Bader, G., Berger, H., Caligiuri, M., … Koegl, M. (2017). Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Reports, 20(12), 2860-2875. https://doi.org/10.1016/j.celrep.2017.08.081
Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight
Rajabi, N., Auth, M., Troelsen, K. R., Pannek, M., Bhatt, D. P., Fontenas, M., … Olsen, C. A. (2017). Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight. Angewandte Chemie International Edition, 56(47), 14836-14841. https://doi.org/10.1002/anie.201709050
Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
Engel, J., Becker, C., Lategahn, J., Keul, M., Ketzer, J., Mühlenberg, T., … Rauh, D. (2016). Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR. Angewandte Chemie International Edition, 55(36), 10909-10912. https://doi.org/10.1002/anie.201605011
Identification of a β1/β2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening
Beck, P., Reboud-Ravaux, M., & Groll, M. (2015). Identification of a β1/β2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening. Angewandte Chemie International Edition, 54(38), 11275-11278. https://doi.org/10.1002/anie.201505054
Stabilizer-Guided Inhibition of Protein-Protein Interactions
Milroy, L. G., Bartel, M., Henen, M. A., Leysen, S., Adriaans, J. M. C., Brunsveld, L., … Ottmann, C. (2015). Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angewandte Chemie International Edition, 54(52), 15720-15724. https://doi.org/10.1002/anie.201507976
2-carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1
Neres, J., Hartkoorn, R. C., Chiarelli, L. R., Gadupudi, R., Pasca, M. R., Mori, G., … Cole, S. T. (2015). 2-carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. ACS Chemical Biology, 10(3), 705-714. https://doi.org/10.1021/cb5007163
Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)
Pomplun, S., Wang, Y., Kirschner, A., Kozany, C., Bracher, A., & Hausch, F. (2015). Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs). Angewandte Chemie International Edition, 54(1), 345-348. https://doi.org/10.1002/ANIE.201408776
Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4
Schröder, P., Förster, T., Kleine, S., Becker, C., Richters, A., Ziegler, S., … Waldmann, H. (2015). Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4. Angewandte Chemie International Edition, 54(42), 12398-12403. https://doi.org/10.1002/anie.201501515
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma
Tintori, C., Fallacara, A. L., Radi, M., Zamperini, C., Dreassi, E., Crespan, E., … Botta, M. (2015). Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma. Journal of Medicinal Chemistry, 58(1), 347-361. https://doi.org/10.1021/JM5013159
Pseudilins: Halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD
Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Höffken, H. W., … Diederich, F. (2014). Pseudilins: Halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angewandte Chemie International Edition, 53(8), 2235-2239. https://doi.org/10.1002/anie.201309557
Structural basis of microtubule stabilization by laulimalide and peloruside A
Prota, A. E., Bargsten, K., Northcote, P. T., Marsh, M., Altmann, K. H., Miller, J. H., … Steinmetz, M. O. (2014). Structural basis of microtubule stabilization by laulimalide and peloruside A. Angewandte Chemie International Edition, 53(6), 1621-1625. https://doi.org/10.1002/anie.201307749
A natural-product switch for a dynamic protein interface
Scheepstra, M., Nieto, L., Hirsch, A. K. H., Fuchs, S., Leysen, S., Lam, C. V., … Brunsveld, L. (2014). A natural-product switch for a dynamic protein interface. Angewandte Chemie International Edition, 53(25), 6443-6448. https://doi.org/10.1002/anie.201403773