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Investigations using albumin binders to modify the tissue distribution profile of radiopharmaceuticals exemplified with folate radioconjugates
Busslinger, S. D., Becker, A. E., Vaccarin, C., Deberle, L. M., Renz, M. L., Groehn, V., … Müller, C. (2023). Investigations using albumin binders to modify the tissue distribution profile of radiopharmaceuticals exemplified with folate radioconjugates. Cancers, 15(17), 4259 (19 pp.). https://doi.org/10.3390/cancers15174259
Design and evaluation of novel albumin-binding folate radioconjugates: systematic approach of varying the linker entities
Benešová, M., Guzik, P., Deberle, L. M., Busslinger, S. D., Landolt, T., Schibli, R., & Müller, C. (2022). Design and evaluation of novel albumin-binding folate radioconjugates: systematic approach of varying the linker entities. Molecular Pharmaceutics, 19, 963-973. https://doi.org/10.1021/acs.molpharmaceut.1c00932
Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates - new perspectives for folate receptor-targeted radionuclide therapy
Guzik, P., Benešová, M., Ratz, M., Monné Rodríguez, J. M., Deberle, L. M., Schibli, R., & Müller, C. (2021). Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates - new perspectives for folate receptor-targeted radionuclide therapy. European Journal of Nuclear Medicine and Molecular Imaging, 48, 972-983. https://doi.org/10.1007/s00259-020-04980-y
Promising potential of [<sup>177</sup>Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy - a preclinical study using a syngeneic breast cancer model
Guzik, P., Siwowska, K., Fang, H. Y., Cohrs, S., Bernhardt, P., Schibli, R., & Müller, C. (2021). Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy - a preclinical study using a syngeneic breast cancer model. European Journal of Nuclear Medicine and Molecular Imaging, 48, 984-994. https://doi.org/10.1007/s00259-020-05054-9
Radiation dosimetry of &lt;sup&gt;18&lt;/sup&gt;F-AzaFol: a first in-human use of a folate receptor PET tracer
Gnesin, S., Müller, J., Burger, I. A., Meisel, A., Siano, M., Früh, M., … Schaefer, N. (2020). Radiation dosimetry of 18F-AzaFol: a first in-human use of a folate receptor PET tracer. EJNMMI Research, 10(1), 32 (12 pp.). https://doi.org/10.1186/s13550-020-00624-2
Diastereomerically pure 6&lt;em&gt;R&lt;/em&gt;- and 6&lt;em&gt;S&lt;/em&gt;-3&#039;-aza-2&#039;-&lt;sup&gt;18&lt;/sup&gt;F-fluoro-5-methyltetrahydrofolates show unprecedentedly high uptake in folate receptor-positive KB tumors
Boss, S. D., Müller, C., Siwowska, K., Schmid, R. M., Groehn, V., Schibli, R., & Ametamey, S. M. (2019). Diastereomerically pure 6R- and 6S-3'-aza-2'-18F-fluoro-5-methyltetrahydrofolates show unprecedentedly high uptake in folate receptor-positive KB tumors. Journal of Nuclear Medicine, 60(1), 135-141. https://doi.org/10.2967/jnumed.118.213314
Combination of proton therapy and radionuclide therapy in mice: preclinical pilot sudy at the Paul Scherrer Institute
Müller, C., De Prado Leal, M., Dominietto, M. D., Umbricht, C. A., Safai, S., Perrin, R. L., … Lomax, A. J. (2019). Combination of proton therapy and radionuclide therapy in mice: preclinical pilot sudy at the Paul Scherrer Institute. Pharmaceutics, 11(9), 450 (13 pp.). https://doi.org/10.3390/pharmaceutics11090450
&lt;sup&gt;18&lt;/sup&gt;F-AzaFol for detection of folate receptor-β positive macrophages in experimental interstitial lung disease - a proof-of-concept study
Schniering, J., Benešová, M., Brunner, M., Haller, S., Cohrs, S., Frauenfelder, T., … Maurer, B. (2019). 18F-AzaFol for detection of folate receptor-β positive macrophages in experimental interstitial lung disease - a proof-of-concept study. Frontiers in Immunology, 10, 2724 (15 pp.). https://doi.org/10.3389/fimmu.2019.02724
Therapeutic potential of &lt;sup&gt;47&lt;/sup&gt;Sc in comparison to &lt;sup&gt;177&lt;/sup&gt;Lu and &lt;sup&gt;90&lt;/sup&gt;Y: preclinical investigations
Siwowska, K., Guzik, P., Domnanich, K. A., Monné Rodríguez, J. M., Bernhardt, P., Ponsard, B., … Müller, C. (2019). Therapeutic potential of 47Sc in comparison to 177Lu and 90Y: preclinical investigations. Pharmaceutics, 11(8), 424 (13 pp.). https://doi.org/10.3390/pharmaceutics11080424
Folate receptor-positive gynecological cancer cells: in vitro and in vivo characterization
Siwowska, K., Schmid, R. M., Cohrs, S., Schibli, R., & Müller, C. (2017). Folate receptor-positive gynecological cancer cells: in vitro and in vivo characterization. Pharmaceuticals, 10(3), 72 (17 pp.). https://doi.org/10.3390/ph10030072
&lt;sup&gt;64&lt;/sup&gt;Cu- and &lt;sup&gt;68&lt;/sup&gt;Ga-based PET imaging of folate receptor-positive tumors: development and evaluation of an albumin-binding NODAGA−folate
Farkas, R., Siwowska, K., Ametamey, S. M., Schibli, R., van der Meulen, N. P., & Müller, C. (2016). 64Cu- and 68Ga-based PET imaging of folate receptor-positive tumors: development and evaluation of an albumin-binding NODAGA−folate. Molecular Pharmaceutics, 13(6), 1979-1987. https://doi.org/10.1021/acs.molpharmaceut.6b00143
Preclinical development of small-molecular-weight folate-based radioconjugates: a pharmacological perspective
Siwowska, K., & Müller, C. (2015). Preclinical development of small-molecular-weight folate-based radioconjugates: a pharmacological perspective. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59(3), 269-286.
Direct in vitro and in vivo comparison of &lt;sup&gt;161&lt;/sup&gt;Tb and &lt;sup&gt;177&lt;/sup&gt;Lu using a tumour-targeting folate conjugate
Müller, C., Reber, J., Haller, S., Dorrer, H., Bernhardt, P., Zhernosekov, K., … Schibli, R. (2014). Direct in vitro and in vivo comparison of 161Tb and 177Lu using a tumour-targeting folate conjugate. European Journal of Nuclear Medicine and Molecular Imaging, 41(3), 476-485. https://doi.org/10.1007/s00259-013-2563-z
Folate receptor targeted alpha-therapy using terbium-149
Müller, C., Reber, J., Haller, S., Dorrer, H., Köster, U., Johnston, K., … Schibli, R. (2014). Folate receptor targeted alpha-therapy using terbium-149. Pharmaceuticals, 7(3), 353-365. https://doi.org/10.3390/ph7030353
Promising prospects for <sup>44</sup>Sc-/<sup>47</sup>Sc-based theragnostics: application of <sup>47</sup>Sc for radionuclide tumor therapy in mice
Müller, C., Bunka, M., Haller, S., Köster, U., Groehn, V., Bernhardt, P., … Schibli, R. (2014). Promising prospects for 44Sc-/47Sc-based theragnostics: application of 47Sc for radionuclide tumor therapy in mice. Journal of Nuclear Medicine, 55(10), 1658-1664. https://doi.org/10.2967/jnumed.114.141614
Improved PET imaging of tumors in mice using a novel &lt;sup&gt;18&lt;/sup&gt;F-folate conjugate with an albumin-binding entity
Fischer, C. R., Groehn, V., Reber, J., Schibli, R., Ametamey, S. M., & Müller, C. (2013). Improved PET imaging of tumors in mice using a novel 18F-folate conjugate with an albumin-binding entity. Molecular Imaging and Biology, 15(6), 649-654. https://doi.org/10.1007/s11307-013-0651-x
DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted &lt;sup&gt;177&lt;/sup&gt;Lu-radionuclide tumor therapy in mice
Müller, C., Struthers, H., Winiger, C., Zhernosekov, K., & Schibli, R. (2013). DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted 177Lu-radionuclide tumor therapy in mice. Journal of Nuclear Medicine, 54(1), 124-131. https://doi.org/10.2967/jnumed.112.107235
Folate-based radiotracers for PET imaging - update and perspectives
Müller, C. (2013). Folate-based radiotracers for PET imaging - update and perspectives. Molecules, 18(5), 5005-5031. https://doi.org/10.3390/molecules18055005
Promises of cyclotron-produced <sup>44</sup>Sc as a diagnostic match for trivalent β<sup>-</sup>-emitters: in vitro and in vivo study of a <sup>44</sup>Sc-DOTA-folate conjugate
Müller, C., Bunka, M., Reber, J., Fischer, C., Zhernosekov, K., Türler, A., & Schibli, R. (2013). Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate. Journal of Nuclear Medicine, 54(12), 2168-2174. https://doi.org/10.2967/jnumed.113.123810
Prospects in folate receptor-targeted radionuclide therapy
Müller, C., & Schibli, R. (2013). Prospects in folate receptor-targeted radionuclide therapy. Frontiers in Oncology, 3, 249 (10 pp.). https://doi.org/10.3389/fonc.2013.00249