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Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
Structural basis of microtubule stabilization by discodermolide
Prota, A. E., Bargsten, K., Redondo-Horcajo, M., Smith, A. B., Yang, C. P. H., McDaid, H. M., … Steinmetz, M. O. (2017). Structural basis of microtubule stabilization by discodermolide. ChemBioChem, 18(10), 905-909. https://doi.org/10.1002/cbic.201600696
Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation
Prota, A. E., Setter, J., Waight, A. B., Bargsten, K., Murga, J., Diaz, J. F., & Steinmetz, M. O. (2016). Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation. Journal of Molecular Biology, 428(15), 2981-2988. https://doi.org/10.1016/j.jmb.2016.06.023
Structural basis of microtubule stabilization by laulimalide and peloruside A
Prota, A. E., Bargsten, K., Northcote, P. T., Marsh, M., Altmann, K. H., Miller, J. H., … Steinmetz, M. O. (2014). Structural basis of microtubule stabilization by laulimalide and peloruside A. Angewandte Chemie International Edition, 53(6), 1621-1625. https://doi.org/10.1002/anie.201307749