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  • (-) PSI Authors ≠ Panepucci, Ezequiel
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Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel
Barret, D. C. A., Schuster, D., Rodrigues, M. J., Leitner, A., Picotti, P., Schertler, G. F. X., … Marino, J. (2023). Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. Proceedings of the National Academy of Sciences of the United States of America PNAS, 120(15), e2300309120 (10 pp.). https://doi.org/10.1073/pnas.2300309120
Novel potent and highly selective DDR1 inhibitors from integrated lead finding
Kuhn, B., Ritter, M., Benz, J., Kocer, B., Sarie, J. C., Hochstrasser, R., … Prunotto, M. (2023). Novel potent and highly selective DDR1 inhibitors from integrated lead finding. Medicinal Chemistry Research, 32(7), 1400-1425. https://doi.org/10.1007/s00044-023-03066-2
Structural and biochemical elucidation of class I hybrid cluster protein natively extracted from a marine methanogenic archaeon
Lemaire, O. N., Belhamri, M., & Wagner, T. (2023). Structural and biochemical elucidation of class I hybrid cluster protein natively extracted from a marine methanogenic archaeon. Frontiers in Microbiology, 14, 1179204 (16 pp.). https://doi.org/10.3389/fmicb.2023.1179204
Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
Chrustowicz, J., Sherpa, D., Teyra, J., Loke, M. S., Popowicz, G. M., Basquin, J., … Schulman, B. A. (2022). Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases. Journal of Molecular Biology, 434(2), 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347
The first structure of human MTHFD2L and its implications for the development of isoform-selective inhibitors
Scaletti, E. R., Gustafsson Westergren, R., Andersson, Y., Wiita, E., Henriksson, M., Homan, E. J., … Stenmark, P. (2022). The first structure of human MTHFD2L and its implications for the development of isoform-selective inhibitors. ChemMedChem, 17(18), e202200274 (10 pp.). https://doi.org/10.1002/cmdc.202200274
Efficient production of a functional G protein-coupled receptor in <em>E. coli</em> for structural studies
Abiko, L. A., Rogowski, M., Gautier, A., Schertler, G., & Grzesiek, S. (2021). Efficient production of a functional G protein-coupled receptor in E. coli for structural studies. Journal of Biomolecular NMR, 75(1), 25-38. https://doi.org/10.1007/s10858-020-00354-6
Bragg holography of nano-crystals
Latychevskaia, T., Cassidy, C., & Shintake, T. (2021). Bragg holography of nano-crystals. Ultramicroscopy, 230, 113376 (8 pp.). https://doi.org/10.1016/j.ultramic.2021.113376
Structural insights into protein folding, stability and activity using <em>in vivo</em> perdeuteration of hen egg-white lysozyme
Ramos, J., Laux, V., Haertlein, M., Boeri Erba, E., McAuley, K. E., Forsyth, V. T., … Langkilde, A. E. (2021). Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme. IUCrJ, 8, 372-386. https://doi.org/10.1107/S2052252521001299
Structural basis for inhibition of ROS‐producing respiratory complex I by NADH‐OH
Vranas, M., Wohlwend, D., Qiu, D., Gerhardt, S., Trncik, C., Pervaiz, M., … Friedrich, T. (2021). Structural basis for inhibition of ROS‐producing respiratory complex I by NADH‐OH. Angewandte Chemie International Edition, 60(52), 27277-27281. https://doi.org/10.1002/anie.202112165
Gold standard for macromolecular crystallography diffraction data
Bernstein, H. J., Förster, A., Bhowmick, A., Brewster, A. S., Brockhauser, S., Gelisio, L., … Winter, G. (2020). Gold standard for macromolecular crystallography diffraction data. IUCrJ, 7(5), 784-792. https://doi.org/10.1107/S2052252520008672
L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ
Gellrich, L., Heitel, P., Heering, J., Kilu, W., Pollinger, J., Goebel, T., … Merk, D. (2020). L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ. Journal of Medicinal Chemistry, 63(13), 6727-6740. https://doi.org/10.1021/acs.jmedchem.9b02150
X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains
Larson, E. T., Brennan, D. L., Hickey, E. R., Ganesan, R., Kroe‐Barrett, R., & Farrow, N. A. (2020). X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains. Protein Science, 29(7), 1679-1686. https://doi.org/10.1002/pro.3862
Serial femtosecond <em>zero dose</em> crystallography captures a water-free distal heme site in a dye‐decolourising peroxidase to reveal a catalytic role for an arginine in Fe<sup>IV</sup>=O formation
Lučić, M., Svistunenko, D. A., Wilson, M. T., Chaplin, A. K., Davy, B., Ebrahim, A., … Worrall, J. A. R. (2020). Serial femtosecond zero dose crystallography captures a water-free distal heme site in a dye‐decolourising peroxidase to reveal a catalytic role for an arginine in FeIV=O formation. Angewandte Chemie International Edition, 59(48), 21656-21662. https://doi.org/10.1002/anie.202008622
Fragment-based discovery of non-bisphosphonate binders of <em>Trypanosoma brucei</em> farnesyl pyrophosphate synthase
Münzker, L., Petrick, J. K., Schleberger, C., Clavel, D., Cornaciu, I., Wilcken, R., … Jahnke, W. (2020). Fragment-based discovery of non-bisphosphonate binders of Trypanosoma brucei farnesyl pyrophosphate synthase. ChemBioChem, 21(21), 3096-3111. https://doi.org/10.1002/cbic.202000246
Complex crystal structures of EGFR with third-generation kinase inhibitors and simultaneously bound allosteric ligands
Niggenaber, J., Heyden, L., Grabe, T., Muller, M. P., Lategahn, J., & Rauh, D. (2020). Complex crystal structures of EGFR with third-generation kinase inhibitors and simultaneously bound allosteric ligands. ACS Medicinal Chemistry Letters, 11(12), 2484-2490. https://doi.org/10.1021/acsmedchemlett.0c00472
Sub-pixel electron detection using a convolutional neural network
van Schayck, J. P., van Genderen, E., Maddox, E., Roussel, L., Boulanger, H., Fröjdh, E., … Ravelli, R. B. G. (2020). Sub-pixel electron detection using a convolutional neural network. Ultramicroscopy, 218, 113091 (10 pp.). https://doi.org/10.1016/j.ultramic.2020.113091
Drug design inspired by nature: crystallographic detection of an auto-tailored protease inhibitor template
Gall, F. M., Hohl, D., Frasson, D., Wermelinger, T., Mittl, P. R. E., Sievers, M., & Riedl, R. (2019). Drug design inspired by nature: crystallographic detection of an auto-tailored protease inhibitor template. Angewandte Chemie International Edition, 58(12), 4051-4055. https://doi.org/10.1002/anie.201812348
Structural and mechanistic features of ClyA-like α-pore-forming toxins
Bräuning, B., & Groll, M. (2018). Structural and mechanistic features of ClyA-like α-pore-forming toxins. Toxins, 10(9), 343 (9 pp.). https://doi.org/10.3390/toxins10090343
Ligand channel in pharmacologically stabilized rhodopsin
Mattle, D., Kuhn, B., Aebi, J., Bedoucha, M., Kekilli, D., Grozinger, N., … Dawson, R. J. P. (2018). Ligand channel in pharmacologically stabilized rhodopsin. Proceedings of the National Academy of Sciences of the United States of America PNAS, 115(14), 3640-3645. https://doi.org/10.1073/pnas.1718084115
AibA/AibB induces an intramolecular decarboxylation in isovalerate biosynthesis by <em>Myxococcus xanthus</em>
Bock, T., Luxenburger, E., Hoffmann, J., Schütza, V., Feiler, C., Müller, R., & Blankenfeldt, W. (2017). AibA/AibB induces an intramolecular decarboxylation in isovalerate biosynthesis by Myxococcus xanthus. Angewandte Chemie International Edition, 56(33), 9986-9989. https://doi.org/10.1002/anie.201701992