Land use can exert a powerful influence on ecological systems, yet our understanding of the natural and social factors that influence land use and landcover change is incomplete. We studied land-cover change in an area of about 8800 km² along the lower part of the Wisconsin River, a landscape largely dominated by agriculture. Our goals were (a) to quantify changes in land cover between 1938 and 1992, (b) to evaluate the influence of abiotic and socioeconomic variables on land cover in 1938 and 1992, and (c) to characterize the major processes of land-cover change between these two points in time. The results showed a general shift from agricultural land to forest. Cropland declined from covering 44% to 32% of the study area, while forests and grassland both increased (from 32% to 38% and from 10% to 14% respectively). Multiple linear regressions using three abiotic and two socioeconomic variables captured 6% to 36% of the variation in land-cover categories in 1938 and 9% to 46% of the variation in 1992. Including socioeconomic variables always increased model performance. Agricultural abandonment and a general decline in farming intensity were the most important processes of land-cover change among the processes considered. Areas characterized by the different processes of land-cover change differed in the abiotic and socioeconomic variables that had explanatory power and can be distinguished spatially. Understanding the dynamics of landscapes dominated by human impacts requires methods to incorporate socioeconomic variables and anthropogenic processes in the analyses. Our method of hypothesizing and testing major anthropogenic processes may be a useful tool for studying the dynamics of cultural landscapes.