Advances in Land System Science (LSS) rely on the evidence generated by different types of research activities, including place-based case studies, landscape/land-system mapping and synthesis research. However, these activities are usually conducted in parallel, with a lack of integration often leading to important knowledge gaps and limitations. In this article, we provide tools for the application of geographic similarity analysis (GSA), a collection of spatially-explicit methods assessing the degree of similarity between geographic locations, and thereby help to address these limitations. We identify opportunities for employing GSA to support: 1) selecting geographically representative sets of case studies; 2) integrating empirical evidence generated at different scales and levels of abstraction; and 3) facilitating context-sensitive knowledge transfer. The resulting toolbox provides approaches for facilitating researchers to get an enhanced understanding of multi-scale land change processes, as well as supporting land governance in scaling up the knowledge and solutions generated by LSS research.