On August 10, 2019, typhoon "Lekima" and the associated heavy rainfall triggered a large landslide in Yongjia County, Zhejiang, China. The sliding mass blocked the river, resulted in an air blast and barrier lake disaster chain, and caused 32 deaths. A thorough survey was performed to investigate the characteristics and possible failure mechanisms of the event. The landslide initiation is caused by the combination of rock mass characteristics, wind load, heavy rainfall, and human activities. The presence of roots and cracks in the strongly weathered tuff provides preferential infiltration channels for the rainwater penetration, causing the rapid destabilization of the slope. Furthermore, we used the dynamic model RAMMS and empirical equations to analyze the disaster-causing process of the landslide. Results indicated that the landslide movement lasted for about 30 s with a maximum velocity of 21 m/s. The generated air blast shows a maximum pressure of 1.7 kPa and caused tree breakage on the opposite side of the river. Subsequently, the sliding mass blocked the river and generated a landslide dam with a maximum thickness of about 14 m. Its combination with heavy rainfall led to the rise of the upstream water level and the submersion of houses in the Shanzao village within 20 min. Our work is expected to improve the understanding of typhoon-induced large landslides and promote the risk assessment of this type of geohazard in coastal regions.