Local and potentially more impactful regional floods are driven by a combination of precipitation-triggering storms and antecedent conditions. However, it is yet unclear how the importance of these flood drivers and their interplay differs between local and regional events. Therefore, we assess differences in the compounding drivers of local and regional floods in the United States using newly developed classification schemes for storm types and antecedent conditions. Our results show that the dominant storm type triggering floods is frontal events, in particular those related to mesoscale convective systems. The importance of different storm types varies by season, with frontal mesoscale convective systems being most important in summer, nonfrontal, and extratropical cyclone-related storms in winter and spring, and tropical cyclones in fall. Our comparison of the drivers of local and regional events shows that the relative importance of different storm types only weakly differs between local and regional floods, while antecedent conditions are clearly distinct. Regional events are in 75% of the cases related to wet antecedent conditions in some cases combined with snowmelt, while local events are more likely to also develop under dry conditions. Over all regions and seasons, regional events are most often the result of a frontal storm combined with wet antecedent conditions, which highlights the important role of compounding flood drivers. This finding suggests that regional flood risk and change assessments should account for the compounding nature of atmospheric and land-surface flood drivers.